Homo sapiens Gene: ABCG4
Summary
InnateDB Gene IDBG-74335.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ABCG4
Gene Name ATP-binding cassette, sub-family G (WHITE), member 4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000172350
Encoded Proteins
ATP-binding cassette, sub-family G (WHITE), member 4
ATP-binding cassette, sub-family G (WHITE), member 4
ATP-binding cassette, sub-family G (WHITE), member 4
ATP-binding cassette, sub-family G (WHITE), member 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily and is expressed predominantly in liver tissue. The function has not yet been determined but may involve cholesterol transport. Alternate splice variants have been described but their full length sequences have not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:119149012-119162653
Strand Forward strand
Band q23.3
Transcripts
ENST00000524604 ENSP00000431915
ENST00000533694
ENST00000534402
ENST00000619701 ENSP00000481728
ENST00000615496 ENSP00000479253
ENST00000622721 ENSP00000484289
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATPase activity
GO:0017127 cholesterol transporter activity
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006200 ATP catabolic process
GO:0033344 cholesterol efflux
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Transmembrane transport of small molecules pathway
ABCA transporters in lipid homeostasis pathway
ABC-family proteins mediated transport pathway
KEGG
ABC transporters pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9H172
TrEMBL E9PJ00 Q9NT30
UniProt Splice Variant
Entrez Gene 64137
UniGene
RefSeq NM_022169 NM_001142505
HUGO HGNC:13884
OMIM 607784
CCDS CCDS8415
HPRD
IMGT
EMBL AJ300465 AJ308237 AK289830 AK290035 AL137563 AP002956 AY055472 BC041091 CH471065
GenPept AAH41091 AAL16400 AAL16401 AAL16402 BAF82519 BAF82724 CAB70814 CAC17140 CAC87131 EAW67464 EAW67465 EAW67466
RNA Seq Atlas 64137