Homo sapiens Gene: SGMS1
Summary
InnateDB Gene IDBG-74409.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SGMS1
Gene Name sphingomyelin synthase 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000198964
Encoded Proteins
sphingomyelin synthase 1
sphingomyelin synthase 1
sphingomyelin synthase 1
sphingomyelin synthase 1
sphingomyelin synthase 1
sphingomyelin synthase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is predicted to be a five-pass transmembrane protein. This gene may be predominately expressed in brain. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:50305586-50625163
Strand Reverse strand
Band q11.23
Transcripts
ENST00000361543 ENSP00000355235
ENST00000361781 ENSP00000354829
ENST00000429490 ENSP00000406795
ENST00000492601
ENST00000498514
ENST00000602619 ENSP00000473668
ENST00000602565 ENSP00000475427
ENST00000609445
ENST00000608287
ENST00000619438 ENSP00000479633
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0005515 protein binding
GO:0016301 kinase activity
GO:0033188 sphingomyelin synthase activity
GO:0047493 ceramide cholinephosphotransferase activity
Biological Process
GO:0006665 sphingolipid metabolic process
GO:0006686 sphingomyelin biosynthetic process
GO:0006915 apoptotic process
GO:0006954 inflammatory response
GO:0010628 positive regulation of gene expression
GO:0016049 cell growth
GO:0016310 phosphorylation
GO:0030148 sphingolipid biosynthetic process
GO:0044281 small molecule metabolic process
GO:0071222 cellular response to lipopolysaccharide
GO:0071356 cellular response to tumor necrosis factor
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0000138 Golgi trans cisterna
GO:0000139 Golgi membrane
GO:0005634 nucleus
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030173 integral component of Golgi membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Sphingolipid metabolism pathway
Metabolism of lipids and lipoproteins pathway
Sphingolipid de novo biosynthesis pathway
Metabolism pathway
KEGG
Sphingolipid metabolism pathway
INOH
PID BIOCARTA
PID NCI
IL2 signaling events mediated by PI3K
Cross-References
SwissProt
TrEMBL C0MHM2
UniProt Splice Variant
Entrez Gene 259230
UniGene
RefSeq NM_147156 XM_005269675
HUGO HGNC:29799
OMIM 611573
CCDS CCDS7240
HPRD
IMGT
EMBL FM210200 FN870365
GenPept CAR65042 CBM41470
RNA Seq Atlas 259230