Version 5.4
Mus musculus Gene: Sgms1
Summary
InnateDB Gene IDBG-158524.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sgms1
Gene Name sphingomyelin synthase 1
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000040451
Encoded Proteins
IDBP-158528
sphingomyelin synthase 1
IDBP-539829
sphingomyelin synthase 1
IDBP-540394
sphingomyelin synthase 1
IDBP-532563
sphingomyelin synthase 1
IDBP-540829
sphingomyelin synthase 1
IDBP-542033
sphingomyelin synthase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198964:
The protein encoded by this gene is predicted to be a five-pass transmembrane protein. This gene may be predominately expressed in brain. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:32122727-32389714
Strand Reverse strand
Band C1
Transcripts
ENSMUST00000099514 ENSMUSP00000097114
ENSMUST00000142618 ENSMUSP00000117336
ENSMUST00000151289 ENSMUSP00000123395
ENSMUST00000152340 ENSMUSP00000119869
ENSMUST00000134415 ENSMUSP00000115785
ENSMUST00000124012
ENSMUST00000151822 ENSMUSP00000114683
ENSMUST00000149107
ENSMUST00000141655
ENSMUST00000131768
ENSMUST00000149934
ENSMUST00000124483
ENSMUST00000126332
ENSMUST00000141252
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0005515 protein binding
GO:0016301 kinase activity
GO:0033188 sphingomyelin synthase activity
GO:0047493 ceramide cholinephosphotransferase activity
Biological Process
GO:0006686 sphingomyelin biosynthetic process
GO:0006915 apoptotic process
GO:0006954 inflammatory response
GO:0010628 positive regulation of gene expression
GO:0016049 cell growth
GO:0016310 phosphorylation
GO:0071222 cellular response to lipopolysaccharide
GO:0071356 cellular response to tumor necrosis factor
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0000138 Golgi trans cisterna
GO:0005634 nucleus
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030173 integral component of Golgi membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000198964
View Gene Order
ENSBTAG00000011748
Not yet available
Pathways
NETPATH
REACTOME
REACT_198151
Sphingolipid de novo biosynthesis pathway
REACT_188937
Metabolism pathway
REACT_245163
Sphingolipid metabolism pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
KEGG
mmu00600
Sphingolipid metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_115810
Sphingolipid de novo biosynthesis pathway
REACT_19323
Sphingolipid metabolism pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_111217
Metabolism pathway
KEGG
hsa00600
Sphingolipid metabolism pathway
INOH
PID NCI
il2_pi3kpathway
IL2 signaling events mediated by PI3K
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.329810 Mm.444083
RefSeq NM_001168525 NM_001168526 NM_144792 XM_006526817 XM_006526818 XM_006526819 XM_006526820
OMIM
CCDS CCDS29750
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca