InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: DLX1

Summary

InnateDB Gene

IDBG-75048.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DLX1

Gene Name

distal-less homeobox 1

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000144355

Encoded Proteins

IDBP-75050

distal-less homeobox 1

IDBP-75052

distal-less homeobox 1

IDBP-75054

distal-less homeobox 1

IDBP-589149

distal-less homeobox 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of a homeobox transcription factor gene family similiar to the Drosophila distal-less gene. The encoded protein is localized to the nucleus where it may function as a transcriptional regulator of signals from multiple TGF-{beta} superfamily members. The encoded protein may play a role in the control of craniofacial patterning and the differentiation and survival of inhibitory neurons in the forebrain. This gene is located in a tail-to-tail configuration with another member of the family on the long arm of chromosome 2. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:172084740-172089677

Strand

Forward strand

Band

q31.1

Transcripts

ENST00000361725	ENSP00000354478
ENST00000361609	ENSP00000354865
ENST00000341900	ENSP00000341786
ENST00000409492
ENST00000469444	ENSP00000448827
ENST00000475989
ENST00000550686

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000976	transcription regulatory region sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0009954	proximal/distal pattern formation
GO:0021544	subpallium development
GO:0021766	hippocampus development
GO:0021879	forebrain neuron differentiation
GO:0021882	regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment
GO:0021892	cerebral cortex GABAergic interneuron differentiation
GO:0021893	cerebral cortex GABAergic interneuron fate commitment
GO:0030154	cell differentiation
GO:0042475	odontogenesis of dentin-containing tooth
GO:0043524	negative regulation of neuron apoptotic process
GO:0045746	negative regulation of Notch signaling pathway
GO:0048706	embryonic skeletal system development
GO:0048715	negative regulation of oligodendrocyte differentiation

Cellular Component

GO:0005634

nucleus

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000041911

View Gene Order

ENSBTAG00000015217

Not yet available

Pathways

NETPATH

REACTOME

KEGG

INOH

PID NCI

smad2_3nuclearpathway

Regulation of nuclear SMAD2/3 signaling

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.407015 Hs.613853 Hs.625055

RefSeq

NM_001038493 NM_178120

HUGO

OMIM

CCDS

CCDS2247 CCDS33328

HPRD

08961

IMGT

EMBL

GenPept

RNA Seq Atlas