Homo sapiens Gene: DLX1
Summary
InnateDB Gene IDBG-75048.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DLX1
Gene Name distal-less homeobox 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000144355
Encoded Proteins
distal-less homeobox 1
distal-less homeobox 1
distal-less homeobox 1
distal-less homeobox 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of a homeobox transcription factor gene family similiar to the Drosophila distal-less gene. The encoded protein is localized to the nucleus where it may function as a transcriptional regulator of signals from multiple TGF-{beta} superfamily members. The encoded protein may play a role in the control of craniofacial patterning and the differentiation and survival of inhibitory neurons in the forebrain. This gene is located in a tail-to-tail configuration with another member of the family on the long arm of chromosome 2. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:172084740-172089677
Strand Forward strand
Band q31.1
Transcripts
ENST00000361725 ENSP00000354478
ENST00000361609 ENSP00000354865
ENST00000341900 ENSP00000341786
ENST00000409492
ENST00000469444 ENSP00000448827
ENST00000475989
ENST00000550686
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000976 transcription regulatory region sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0009954 proximal/distal pattern formation
GO:0021544 subpallium development
GO:0021766 hippocampus development
GO:0021879 forebrain neuron differentiation
GO:0021882 regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment
GO:0021892 cerebral cortex GABAergic interneuron differentiation
GO:0021893 cerebral cortex GABAergic interneuron fate commitment
GO:0030154 cell differentiation
GO:0042475 odontogenesis of dentin-containing tooth
GO:0043524 negative regulation of neuron apoptotic process
GO:0045746 negative regulation of Notch signaling pathway
GO:0048706 embryonic skeletal system development
GO:0048715 negative regulation of oligodendrocyte differentiation
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Regulation of nuclear SMAD2/3 signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.407015 Hs.613853 Hs.625055
RefSeq NM_001038493 NM_178120
HUGO
OMIM
CCDS CCDS2247 CCDS33328
HPRD 08961
IMGT
EMBL
GenPept
RNA Seq Atlas