InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MAFB

Summary

InnateDB Gene

IDBG-75124.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAFB

Gene Name

v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)

Synonyms

KRML; MCTO;

Species

Homo sapiens

Ensembl Gene

ENSG00000204103

Encoded Proteins

IDBP-75126

v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 20581830

MAFB binds to IRF3, impairing the recruitment of co-activators to IRF3 and antagonizing antiviral responses.

Entrez Gene

Summary

The protein encoded by this gene is a basic leucine zipper (bZIP) transcription factor that plays an important role in the regulation of lineage-specific hematopoiesis. The encoded nuclear protein represses ETS1-mediated transcription of erythroid-specific genes in myeloid cells. This gene contains no introns. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 20:40685848-40689240

Strand

Reverse strand

Band

q12

Transcripts

ENST00000373313

ENSP00000362410

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	21 [view]
Protein-Protein	19 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007379	segment specification
GO:0007423	sensory organ development
GO:0007585	respiratory gaseous exchange
GO:0021571	rhombomere 5 development
GO:0021572	rhombomere 6 development
GO:0033077	T cell differentiation in thymus
GO:0035284	brain segmentation
GO:0042472	inner ear morphogenesis
GO:0045087	innate immune response (InnateDB)
GO:0045647	negative regulation of erythrocyte differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048538	thymus development

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

Method

Confidence

Comments

ENSMUSG00000074622

View Gene Order

Ortholuge

SSD Ortholog

Ortholog supports species divergence

ENSBTAG00000003396

Not yet available

Ortholuge

SSD Ortholog

Ortholog supports species divergence

Cross-References

SwissProt

Q9Y5Q3

TrEMBL

UniProt Splice Variant

Entrez Gene

9935

UniGene

Hs.169487 Hs.709929 Hs.718691

RefSeq

NM_005461

HUGO

HGNC:6408

OMIM

608968

CCDS

CCDS13311

HPRD

07129

IMGT

EMBL

AF134157 AK027324 AL035665 BC028098 BC036689 CH471077

GenPept

AAD30106 AAH28098 AAH36689 BAG51303 CAB75863 EAW76000

RNA Seq Atlas

9935