Version 5.4
Homo sapiens Gene: CIR1
Summary
InnateDB Gene IDBG-75361.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CIR1
Gene Name corepressor interacting with RBPJ, 1
Synonyms CIR
Species Homo sapiens
Ensembl Gene ENSG00000138433
Encoded Proteins
IDBP-35705
corepressor interacting with RBPJ, 1
IDBP-75365
corepressor interacting with RBPJ, 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 2:174348022-174395715
Strand Reverse strand
Band q31.1
Transcripts
ENST00000377973 ENSP00000367211
ENST00000342016 ENSP00000339723
ENST00000464393
ENST00000461454
ENST00000472169
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 20 [view]
Protein-Protein 16 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
Biological Process
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0000118 histone deacetylase complex
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005815 microtubule organizing center
GO:0016607 nuclear speck
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000041777
View Gene Order
ENSBTAG00000038620
Not yet available
Pathways
NETPATH
NetPath_3
Notch pathway
REACTOME
KEGG
hsa04330
Notch signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt Q86X95
TrEMBL
UniProt Splice Variant
Entrez Gene 9541
UniGene Hs.632531 Hs.709031
RefSeq NM_004882
HUGO HGNC:24217
OMIM 605228
CCDS CCDS2256
HPRD
IMGT
EMBL AC018470 AF098297 AK292389 BC015040 BC021175 BC038987 BC046098 U03644
GenPept AAA17853 AAD05243 AAH21175 AAH38987 AAH46098 AAY24216 BAF85078
RNA Seq Atlas 9541

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca