InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CIR1

Summary

InnateDB Protein

IDBP-75365.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CIR1

Protein Name

corepressor interacting with RBPJ, 1

Synonyms

CIR;

Species

Homo sapiens

Ensembl Protein

ENSP00000339723

InnateDB Gene

IDBG-75361 (CIR1)

Protein Structure

UniProt Annotation

Function

May modulate splice site selection during alternative splicing of pre-mRNAs (By similarity). Regulates transcription and acts as corepressor for RBPJ. Recruits RBPJ to the Sin3-histone deacetylase complex (HDAC). Required for RBPJ-mediated repression of transcription. {ECO:0000250, ECO:0000269PubMed:19409814, ECO:0000269PubMed:9874765}.

Subcellular Localization

Nucleus speckle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with NEK6 in the centrosome.

Disease Associations

Tissue Specificity

Highly expressed in heart, brain, placenta, liver, skeletal muscle and pancreas. {ECO:0000269PubMed:9874765}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	20 [view]
Protein-Protein	16 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding

Biological Process

GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0006397	mRNA processing
GO:0008380	RNA splicing
GO:0045892	negative regulation of transcription, DNA-templated