InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CHEK1

Summary

InnateDB Gene

IDBG-75536.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CHEK1

Gene Name

checkpoint kinase 1

Synonyms

CHK1

Species

Homo sapiens

Ensembl Gene

ENSG00000149554

Encoded Proteins

IDBP-75538

CHK1 checkpoint homolog (S. pombe)

IDBP-384441

CHK1 checkpoint homolog (S. pombe)

IDBP-384443

CHK1 checkpoint homolog (S. pombe)

IDBP-384444

CHK1 checkpoint homolog (S. pombe)

IDBP-808078

checkpoint kinase 1

IDBP-602662

CHK1 checkpoint homolog (S. pombe)

IDBP-808081

checkpoint kinase 1

IDBP-600779

CHK1 checkpoint homolog (S. pombe)

IDBP-590825

CHK1 checkpoint homolog (S. pombe)

IDBP-596256

CHK1 checkpoint homolog (S. pombe)

IDBP-602316

CHK1 checkpoint homolog (S. pombe)

IDBP-597814

CHK1 checkpoint homolog (S. pombe)

IDBP-591559

CHK1 checkpoint homolog (S. pombe)

IDBP-808075

checkpoint kinase 1

IDBP-589216

CHK1 checkpoint homolog (S. pombe)

IDBP-594427

CHK1 checkpoint homolog (S. pombe)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:125625136-125676255

Strand

Forward strand

Band

q24.2

Transcripts

ENST00000278916	ENSP00000278916
ENST00000428830	ENSP00000412504
ENST00000427383	ENSP00000391090
ENST00000438015	ENSP00000388648
ENST00000498122	ENSP00000481614
ENST00000525396	ENSP00000434141
ENST00000532449	ENSP00000481616
ENST00000527013	ENSP00000431525
ENST00000526937	ENSP00000431815
ENST00000534685	ENSP00000432470
ENST00000533778	ENSP00000433103
ENST00000534070	ENSP00000435371
ENST00000524737	ENSP00000432890
ENST00000531607	ENSP00000477588
ENST00000532669	ENSP00000434646
ENST00000531062
ENST00000528276
ENST00000544373	ENSP00000442317

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 109 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	109 [view]
Protein-Protein	102 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	3 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0035402	histone kinase activity (H3-T11 specific)

Biological Process

GO:0000077	DNA damage checkpoint
GO:0000086	G2/M transition of mitotic cell cycle
GO:0006260	DNA replication
GO:0006281	DNA repair
GO:0006468	protein phosphorylation
GO:0006974	cellular response to DNA damage stimulus
GO:0006975	DNA damage induced protein phosphorylation
GO:0010468	regulation of gene expression
GO:0010569	regulation of double-strand break repair via homologous recombination
GO:0010767	regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage
GO:0010972	negative regulation of G2/M transition of mitotic cell cycle
GO:0018107	peptidyl-threonine phosphorylation
GO:0031572	G2 DNA damage checkpoint
GO:0035407	histone H3-T11 phosphorylation
GO:0042127	regulation of cell proliferation
GO:0045839	negative regulation of mitosis
GO:0046602	regulation of mitotic centrosome separation
GO:0048096	chromatin-mediated maintenance of transcription
GO:0071260	cellular response to mechanical stimulus
GO:0071310	cellular response to organic substance
GO:0071313	cellular response to caffeine
GO:0090399	replicative senescence
GO:2000279	negative regulation of DNA biosynthetic process
GO:2000615	regulation of histone H3-K9 acetylation

Cellular Component

GO:0000781	chromosome, telomeric region
GO:0000785	chromatin
GO:0000794	condensed nuclear chromosome
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005657	replication fork
GO:0005813	centrosome
GO:0005829	cytosol
GO:0043231	intracellular membrane-bounded organelle