InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CHEK1

Summary

InnateDB Protein

IDBP-594427.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CHEK1

Protein Name

CHK1 checkpoint homolog (S. pombe)

Synonyms

CHK1;

Species

Homo sapiens

Ensembl Protein

ENSP00000442317

InnateDB Gene

IDBG-75536 (CHEK1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 109 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	109 [view]
Protein-Protein	102 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	3 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0035402	histone kinase activity (H3-T11 specific)

Biological Process

GO:0000077	DNA damage checkpoint
GO:0006260	DNA replication
GO:0006281	DNA repair
GO:0006468	protein phosphorylation
GO:0006974	cellular response to DNA damage stimulus
GO:0006975	DNA damage induced protein phosphorylation
GO:0010569	regulation of double-strand break repair via homologous recombination
GO:0010767	regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage
GO:0018107	peptidyl-threonine phosphorylation
GO:0031572	G2 DNA damage checkpoint
GO:0035407	histone H3-T11 phosphorylation
GO:0045839	negative regulation of mitosis
GO:0046602	regulation of mitotic centrosome separation
GO:0048096	chromatin-mediated maintenance of transcription
GO:0071260	cellular response to mechanical stimulus
GO:0090399	replicative senescence
GO:2000615	regulation of histone H3-K9 acetylation

Cellular Component

GO:0000781	chromosome, telomeric region
GO:0000785	chromatin
GO:0000794	condensed nuclear chromosome
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005813	centrosome
GO:0005829	cytosol
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt