Homo sapiens Gene: HOXD8
Summary
InnateDB Gene IDBG-75735.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HOXD8
Gene Name homeobox D8
Synonyms HOX4; HOX4E; HOX5.4;
Species Homo sapiens
Ensembl Gene ENSG00000175879
Encoded Proteins
homeobox D8
homeobox D8
homeobox D8
homeobox D8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. In addition to effects during embryogenesis, this particular gene may also play a role in adult urogenital tract function. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010]
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5\' end of this cluster have been associated with severe limb and genital abnormalities. In addition to effects during embryogenesis, this particular gene may also play a role in adult urogenital tract function. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:176129694-176132695
Strand Forward strand
Band q31.1
Transcripts
ENST00000313173 ENSP00000315949
ENST00000429017 ENSP00000406045
ENST00000450510 ENSP00000409026
ENST00000544999 ENSP00000437431
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007275 multicellular organismal development
GO:0008595 anterior/posterior axis specification, embryo
GO:0009952 anterior/posterior pattern specification
GO:0048705 skeletal system morphogenesis
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Cross-References
SwissProt P13378
TrEMBL F8VSA3
UniProt Splice Variant
Entrez Gene 3234
UniGene Hs.301963
RefSeq NM_001199746 NM_019558 NM_001199747
HUGO HGNC:5139
OMIM 142985
CCDS CCDS2268 CCDS56149 CCDS56148
HPRD 00868
IMGT
EMBL AC009336 AL520835 AY014303 AY014304 BC038709 BC090853 X15507
GenPept AAG42152 AAH38709 AAH90853 CAA33529
RNA Seq Atlas 3234