Homo sapiens Gene: HOXD8 | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Gene | IDBG-75735.6 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | HOXD8 | ||||||||||||||||||
Gene Name | homeobox D8 | ||||||||||||||||||
Synonyms | HOX4; HOX4E; HOX5.4 | ||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Gene | ENSG00000175879 | ||||||||||||||||||
Encoded Proteins |
homeobox D8
homeobox D8
homeobox D8
homeobox D8
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Protein Structure | |||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
Entrez Gene | |||||||||||||||||||
Summary |
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. In addition to effects during embryogenesis, this particular gene may also play a role in adult urogenital tract function. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010] This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5\' end of this cluster have been associated with severe limb and genital abnormalities. In addition to effects during embryogenesis, this particular gene may also play a role in adult urogenital tract function. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010] |
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Gene Information | |||||||||||||||||||
Type | Protein coding | ||||||||||||||||||
Genomic Location | Chromosome 2:176129694-176132695 | ||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||
Band | q31.1 | ||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||
Species
Mus musculus
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Gene ID
Gene Order
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Cross-References | |||||||||||||||||||
SwissProt | P13378 | ||||||||||||||||||
TrEMBL | F8VSA3 | ||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 3234 | ||||||||||||||||||
UniGene | Hs.301963 | ||||||||||||||||||
RefSeq | NM_001199746 NM_001199747 NM_019558 | ||||||||||||||||||
HUGO | HGNC:5139 | ||||||||||||||||||
OMIM | 142985 | ||||||||||||||||||
CCDS | CCDS2268 CCDS56148 CCDS56149 | ||||||||||||||||||
HPRD | 00868 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AC009336 AL520835 AY014303 AY014304 BC038709 BC090853 X15507 | ||||||||||||||||||
GenPept | AAG42152 AAH38709 AAH90853 CAA33529 | ||||||||||||||||||
RNA Seq Atlas | 3234 | ||||||||||||||||||