InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Hoxd8

Summary

InnateDB Gene

IDBG-181129.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hoxd8

Gene Name

homeobox D8

Synonyms

4921540P06Rik; AI047735; Hox-4.3; Hox-5.4

Species

Mus musculus

Ensembl Gene

ENSMUSG00000027102

Encoded Proteins

IDBP-179156

homeobox D8

IDBP-181131

homeobox D8

IDBP-534761

homeobox D8

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000175879:
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. In addition to effects during embryogenesis, this particular gene may also play a role in adult urogenital tract function. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010]
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5\' end of this cluster have been associated with severe limb and genital abnormalities. In addition to effects during embryogenesis, this particular gene may also play a role in adult urogenital tract function. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:74704615-74707933

Strand

Forward strand

Band

Transcripts

ENSMUST00000074721	ENSMUSP00000088094
ENSMUST00000019749	ENSMUSP00000019749
ENSMUST00000151380	ENSMUSP00000118904

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0009952	anterior/posterior pattern specification
GO:0048705	skeletal system morphogenesis

Cellular Component

GO:0005575	cellular_component
GO:0005634	nucleus

Orthologs

Species

Homo sapiens

Gene ID

Gene Order

ENSG00000175879

View Gene Order

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.280673 Mm.407633

RefSeq

NM_001290730 NM_001290731 NM_008276 XM_006498790

OMIM

CCDS

CCDS16143 CCDS71077

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas