Homo sapiens Gene: VPS39
Summary
InnateDB Gene IDBG-7574.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol VPS39
Gene Name vacuolar protein sorting 39 homolog (S. cerevisiae)
Synonyms hVam6p; TLP; VAM6;
Species Homo sapiens
Ensembl Gene ENSG00000166887
Encoded Proteins
vacuolar protein sorting 39 homolog (S. cerevisiae)
vacuolar protein sorting 39 homolog (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that may promote clustering and fusion of late endosomes and lysosomes. The protein may also act as an adaptor protein that modulates the transforming growth factor-beta response by coupling the transforming growth factor-beta receptor complex to the Smad pathway. [provided by RefSeq, Jul 2008]
This gene encodes a protein that may promote clustering and fusion of late endosomes and lysosomes. The protein may also act as an adaptor protein that modulates the transforming growth factor-beta response by coupling the transforming growth factor-beta receptor complex to the Smad pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:42158701-42208316
Strand Reverse strand
Band q15.1
Transcripts
ENST00000318006 ENSP00000326534
ENST00000348544 ENSP00000335193
ENST00000570023
ENST00000563692
ENST00000561797
ENST00000562662
ENST00000570062
ENST00000564994 ENSP00000457325
ENST00000568755
ENST00000568029
ENST00000561818
ENST00000568357
ENST00000562258
ENST00000614932
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005083 small GTPase regulator activity
GO:0005515 protein binding
Biological Process
GO:0006886 intracellular protein transport
GO:0016192 vesicle-mediated transport
GO:0050790 regulation of catalytic activity
Cellular Component
GO:0005765 lysosomal membrane
GO:0030897 HOPS complex
GO:0031902 late endosome membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
TGF_beta_Receptor pathway
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.603177 Hs.88025
RefSeq NM_001301138 NM_015289 XM_005254259
HUGO
OMIM
CCDS CCDS10083 CCDS73710
HPRD 10300
IMGT
EMBL
GenPept
RNA Seq Atlas