Version 5.4
Homo sapiens Gene: TRIM15
Summary
InnateDB Gene IDBG-75795.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRIM15
Gene Name tripartite motif containing 15
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000204610
Encoded Proteins
IDBP-75799
tripartite motif containing 15
IDBP-75805
tripartite motif containing 15
IDBP-368394
tripartite motif containing 15
IDBP-808656
tripartite motif containing 15
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 23077300
TRIM15 is required for RIG-I mediated interferon production to inhibit viral replication.
PMID 23438823
TRIM15 was identified in a systematic screen for positive regulators of innate immune responses.
Entrez Gene
Summary The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the cytoplasm. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:30163206-30172696
Strand Forward strand
Band p22.1
Transcripts
ENST00000376694 ENSP00000365884
ENST00000376688 ENSP00000365878
ENST00000433744 ENSP00000398285
ENST00000477944
ENST00000619857 ENSP00000484001
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated
Total 13 [view]
Protein-Protein 12 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0007500 mesodermal cell fate determination
GO:0032481 positive regulation of type I interferon production
GO:0045087 innate immune response (InnateDB)
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:1900246 positive regulation of RIG-I signaling pathway
GO:1901253 negative regulation of intracellular transport of viral material
GO:1902187 negative regulation of viral release from host cell
Cellular Component
GO:0005622 intracellular
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000050747
View Gene Order
ENSBTAG00000007532
Not yet available
Cross-References
SwissProt Q9C019
TrEMBL Q5SRL0
UniProt Splice Variant
Entrez Gene 89870
UniGene Hs.591789 Hs.606488
RefSeq NM_033229 XM_005249471
HUGO HGNC:16284
OMIM
CCDS CCDS4677
HPRD
IMGT
EMBL AB088089 AB202085 AF220132 AF220133 AK291853 BA000025 BC038585 BX005441 BX248419 CH471081 CR759838 U34249
GenPept AAD03787 AAG53505 AAG53506 AAH38585 BAB63331 BAC54922 BAE78606 BAF84542 CAM26028 CAM26239 CAQ11093 EAX03271
RNA Seq Atlas 89870

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca