Version 5.4
Homo sapiens Gene: TNIP2
Summary
InnateDB Gene IDBG-7609.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TNIP2
Gene Name TNFAIP3 interacting protein 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000168884
Encoded Proteins
IDBP-7613
TNFAIP3 interacting protein 2
IDBP-481318
TNFAIP3 interacting protein 2
IDBP-485201
TNFAIP3 interacting protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary TNIP2 binds to the C-terminal zinc finger domain of A20 (TNFAIP3; MIM 191163) and is involved in activation of the ERK (see MAPK3; MIM 601795) MAP kinase pathway in various cell types (Van Huffel et al., 2001 [PubMed 11390377]; Papoutsopoulou et al., 2006 [PubMed 16633345]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:2741648-2756376
Strand Reverse strand
Band p16.3
Transcripts
ENST00000315423 ENSP00000321203
ENST00000510267 ENSP00000427613
ENST00000503235 ENSP00000426314
ENST00000502256
ENST00000505186
ENST00000507686
ENST00000511352
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 34 [view]
Protein-Protein 34 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019901 protein kinase binding
GO:0031593 polyubiquitin binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006915 apoptotic process
GO:0006954 inflammatory response
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0023035 CD40 signaling pathway
GO:0034134 toll-like receptor 2 signaling pathway
GO:0034138 toll-like receptor 3 signaling pathway
GO:0034162 toll-like receptor 9 signaling pathway
GO:0043032 positive regulation of macrophage activation
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0050821 protein stabilization
GO:0050871 positive regulation of B cell activation
GO:0070498 interleukin-1-mediated signaling pathway
GO:0071222 cellular response to lipopolysaccharide
GO:2000352 negative regulation of endothelial cell apoptotic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000059866
View Gene Order
ENSBTAG00000015126
Not yet available
Pathways
NETPATH
NetPath_9
TNFalpha pathway
REACTOME
REACT_22442
Interleukin-1 signaling pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_6900
Immune System pathway
REACT_22232
Signaling by Interleukins pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.368551
RefSeq NM_001161527 NM_001292016 NM_024309 XM_005248010
HUGO
OMIM
CCDS CCDS3362 CCDS54714 CCDS75093
HPRD 18207
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca