InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TNIP2

Summary

InnateDB Protein

IDBP-481318.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TNIP2

Protein Name

TNFAIP3 interacting protein 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000427613

InnateDB Gene

IDBG-7609 (TNIP2)

Protein Structure

UniProt Annotation

Function

Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes. {ECO:0000269PubMed:12595760, ECO:0000269PubMed:12753905, ECO:0000269PubMed:12933576, ECO:0000269PubMed:14653779, ECO:0000269PubMed:15169888, ECO:0000269PubMed:21784860}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:12595760}. Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Ubiquitously expressed in all tissues examined. {ECO:0000269PubMed:12595760}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	34 [view]
Protein-Protein	34 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0031593	polyubiquitin binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006915	apoptotic process
GO:0006954	inflammatory response
GO:0023035	CD40 signaling pathway
GO:0034134	toll-like receptor 2 signaling pathway
GO:0034138	toll-like receptor 3 signaling pathway
GO:0034162	toll-like receptor 9 signaling pathway
GO:0043032	positive regulation of macrophage activation
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050821	protein stabilization
GO:0050871	positive regulation of B cell activation
GO:0070498	interleukin-1-mediated signaling pathway
GO:0071222	cellular response to lipopolysaccharide
GO:2000352	negative regulation of endothelial cell apoptotic process