Homo sapiens Gene: ASPN
Summary
InnateDB Gene IDBG-76212.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ASPN
Gene Name asporin
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000106819
Encoded Proteins
asporin
asporin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a cartilage extracellular protein that is member of the small leucine-rich proteoglycan family. The encoded protein may regulate chondrogenesis by inhibiting transforming growth factor-beta 1-induced gene expression in cartilage. This protein also binds collagen and calcium and may induce collagen mineralization. Polymorphisms in the aspartic acid repeat region of this gene are associated with a susceptibility to osteoarthritis. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:92456205-92482506
Strand Reverse strand
Band q22.31
Transcripts
ENST00000375544 ENSP00000364694
ENST00000375543 ENSP00000364693
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005518 collagen binding
Biological Process
GO:0030282 bone mineralization
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0070171 negative regulation of tooth mineralization
Cellular Component
GO:0005578 proteinaceous extracellular matrix
GO:0031012 extracellular matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Extracellular matrix organization pathway
ECM proteoglycans pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL B4E2Z7 Q5TBF2
UniProt Splice Variant
Entrez Gene 54829
UniGene Hs.435655 Hs.664385
RefSeq NM_001193335 NM_017680
HUGO HGNC:14872
OMIM 608135
CCDS
HPRD 16288
IMGT
EMBL AK304501 AL137848 CH471089
GenPept BAG65309 EAW62823
RNA Seq Atlas 54829