Homo sapiens Gene: ADAMTS8 | |||||||||||||||
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Summary | |||||||||||||||
InnateDB Gene | IDBG-76259.6 | ||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||
Gene Symbol | ADAMTS8 | ||||||||||||||
Gene Name | ADAM metallopeptidase with thrombospondin type 1 motif, 8 | ||||||||||||||
Synonyms | ADAM-TS8; METH2 | ||||||||||||||
Species | Homo sapiens | ||||||||||||||
Ensembl Gene | ENSG00000134917 | ||||||||||||||
Encoded Proteins |
ADAM metallopeptidase with thrombospondin type 1 motif, 8
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Protein Structure | |||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||
Entrez Gene | |||||||||||||||
Summary |
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs, and disrupts angiogenesis in vivo. A number of disorders have been mapped in the vicinity of this gene, most notably lung neoplasms. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||
Type | Protein coding | ||||||||||||||
Genomic Location | Chromosome 11:130404925-130428993 | ||||||||||||||
Strand | Reverse strand | ||||||||||||||
Band | q24.3 | ||||||||||||||
Transcripts |
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Interactions | |||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||
NETPATH | |||||||||||||||
REACTOME |
Post-translational protein modification pathway
Extracellular matrix organization pathway
Degradation of the extracellular matrix pathway
O-linked glycosylation pathway
Metabolism of proteins pathway
O-glycosylation of TSR domain-containing proteins pathway
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KEGG | |||||||||||||||
INOH | |||||||||||||||
PID NCI | |||||||||||||||
Cross-References | |||||||||||||||
SwissProt | Q9UP79 | ||||||||||||||
TrEMBL | |||||||||||||||
UniProt Splice Variant | |||||||||||||||
Entrez Gene | 11095 | ||||||||||||||
UniGene | Hs.271605 | ||||||||||||||
RefSeq | NM_007037 XM_006718758 | ||||||||||||||
HUGO | HGNC:224 | ||||||||||||||
OMIM | 605175 | ||||||||||||||
CCDS | CCDS41732 | ||||||||||||||
HPRD | |||||||||||||||
IMGT | |||||||||||||||
EMBL | AF060153 AF175283 AP002986 | ||||||||||||||
GenPept | AAD48081 AAF25806 | ||||||||||||||
RNA Seq Atlas | 11095 | ||||||||||||||