Homo sapiens Gene: ADAMTS8
Summary
InnateDB Gene IDBG-76259.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADAMTS8
Gene Name ADAM metallopeptidase with thrombospondin type 1 motif, 8
Synonyms ADAM-TS8; METH2;
Species Homo sapiens
Ensembl Gene ENSG00000134917
Encoded Proteins
ADAM metallopeptidase with thrombospondin type 1 motif, 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs, and disrupts angiogenesis in vivo. A number of disorders have been mapped in the vicinity of this gene, most notably lung neoplasms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:130404925-130428993
Strand Reverse strand
Band q24.3
Transcripts
ENST00000257359 ENSP00000257359
ENST00000531752
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004222 metalloendopeptidase activity
GO:0005178 integrin binding
GO:0008201 heparin binding
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0009673 low affinity phosphate transmembrane transporter activity
Biological Process
GO:0006508 proteolysis
GO:0008285 negative regulation of cell proliferation
GO:0035435 phosphate ion transmembrane transport
Cellular Component
GO:0005578 proteinaceous extracellular matrix
GO:0031012 extracellular matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Post-translational protein modification pathway
Extracellular matrix organization pathway
Degradation of the extracellular matrix pathway
O-linked glycosylation pathway
Metabolism of proteins pathway
O-glycosylation of TSR domain-containing proteins pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.271605
RefSeq NM_007037 XM_006718758
HUGO
OMIM
CCDS CCDS41732
HPRD 05531
IMGT
EMBL
GenPept
RNA Seq Atlas