Version 5.4
Homo sapiens Gene: ADAMTS8
Summary
InnateDB Gene IDBG-76259.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADAMTS8
Gene Name ADAM metallopeptidase with thrombospondin type 1 motif, 8
Synonyms ADAM-TS8; METH2
Species Homo sapiens
Ensembl Gene ENSG00000134917
Encoded Proteins
IDBP-76261
ADAM metallopeptidase with thrombospondin type 1 motif, 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs, and disrupts angiogenesis in vivo. A number of disorders have been mapped in the vicinity of this gene, most notably lung neoplasms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:130404925-130428993
Strand Reverse strand
Band q24.3
Transcripts
ENST00000257359 ENSP00000257359
ENST00000531752
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004222 metalloendopeptidase activity
GO:0005178 integrin binding
GO:0008201 heparin binding
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0009673 low affinity phosphate transmembrane transporter activity
Biological Process
GO:0006508 proteolysis
GO:0008285 negative regulation of cell proliferation
GO:0035435 phosphate ion transmembrane transport
Cellular Component
GO:0005578 proteinaceous extracellular matrix
GO:0031012 extracellular matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031994
View Gene Order
ENSBTAG00000010411
Not yet available
Pathways
NETPATH
REACTOME
REACT_22161
Post-translational protein modification pathway
REACT_118779
Extracellular matrix organization pathway
REACT_118572
Degradation of the extracellular matrix pathway
REACT_200727
O-linked glycosylation pathway
REACT_17015
Metabolism of proteins pathway
REACT_200626
O-glycosylation of TSR domain-containing proteins pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q9UP79
TrEMBL
UniProt Splice Variant
Entrez Gene 11095
UniGene Hs.271605
RefSeq NM_007037 XM_006718758
HUGO HGNC:224
OMIM 605175
CCDS CCDS41732
HPRD
IMGT
EMBL AF060153 AF175283 AP002986
GenPept AAD48081 AAF25806
RNA Seq Atlas 11095

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca