InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ADAMTS8

Summary

InnateDB Protein

IDBP-76261.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADAMTS8

Protein Name

ADAM metallopeptidase with thrombospondin type 1 motif, 8

Synonyms

ADAM-TS8; METH2;

Species

Homo sapiens

Ensembl Protein

ENSP00000257359

InnateDB Gene

IDBG-76259 (ADAMTS8)

Protein Structure

UniProt Annotation

Function

Has anti-angiogenic properties.

Subcellular Localization

Secreted, extracellular space, extracellular matrix {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in adult and fetal lung, lower expression in brain, placenta, heart, stomach and fetal brain and kidney.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004222	metalloendopeptidase activity
GO:0005178	integrin binding
GO:0008201	heparin binding
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding
GO:0009673	low affinity phosphate transmembrane transporter activity

Biological Process

GO:0006508	proteolysis
GO:0008285	negative regulation of cell proliferation
GO:0035435	phosphate ion transmembrane transport

Cellular Component

GO:0005578	proteinaceous extracellular matrix
GO:0031012	extracellular matrix

Protein Structure and Domains

PDB ID

InterPro

IPR000884 Thrombospondin, type 1 repeat
IPR001590 Peptidase M12B, ADAM/reprolysin
IPR002870 Peptidase M12B, propeptide
IPR006586 ADAM, cysteine-rich
IPR010294 ADAM-TS Spacer 1
IPR013273 Peptidase M12B, ADAM-TS
IPR013277 Peptidase M12B, ADAM-TS8

PFAM

PF00090
PF01421
PF01562
PF08516
PF05986

PRINTS

PR01857
PR01861

PIRSF

SMART

SM00209
SM00608

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt