Homo sapiens Gene: PHF2
Summary
InnateDB Gene IDBG-76769.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PHF2
Gene Name PHD finger protein 2
Synonyms CENP-35; GRC5; JHDM1E;
Species Homo sapiens
Ensembl Gene ENSG00000197724
Encoded Proteins
PHD finger protein 2
PHD finger protein 2
PHD finger protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein which contains a zinc finger-like PHD (plant homeodomain) finger, distinct from other classes of zinc finger motifs, and a hydrophobic and highly conserved domain. The PHD finger shows the typical Cys4-His-Cys3 arrangement. PHD finger genes are thought to belong to a diverse group of transcriptional regulators possibly affecting eukaryotic gene expression by influencing chromatin structure. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:93576407-93679587
Strand Forward strand
Band q22.31
Transcripts
ENST00000359246 ENSP00000352185
ENST00000375376 ENSP00000364525
ENST00000610682 ENSP00000479936
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 4 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003713 transcription coactivator activity
GO:0005506 iron ion binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0032454 histone demethylase activity (H3-K9 specific)
GO:0035064 methylated histone binding
GO:0051213 dioxygenase activity
Biological Process
GO:0001889 liver development
GO:0006351 transcription, DNA-templated
GO:0006482 protein demethylation
GO:0033169 histone H3-K9 demethylation
GO:0055114 oxidation-reduction process
GO:0061188 negative regulation of chromatin silencing at rDNA
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
HDMs demethylate histones pathway
Chromatin organization pathway
Chromatin modifying enzymes pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_005392 XM_005252051
HUGO
OMIM
CCDS CCDS35069
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas