Version 5.4
Homo sapiens Gene: PHF2
Summary
InnateDB Gene IDBG-76769.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PHF2
Gene Name PHD finger protein 2
Synonyms CENP-35; GRC5; JHDM1E
Species Homo sapiens
Ensembl Gene ENSG00000197724
Encoded Proteins
IDBP-76771
PHD finger protein 2
IDBP-76773
PHD finger protein 2
IDBP-806607
PHD finger protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein which contains a zinc finger-like PHD (plant homeodomain) finger, distinct from other classes of zinc finger motifs, and a hydrophobic and highly conserved domain. The PHD finger shows the typical Cys4-His-Cys3 arrangement. PHD finger genes are thought to belong to a diverse group of transcriptional regulators possibly affecting eukaryotic gene expression by influencing chromatin structure. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:93576407-93679587
Strand Forward strand
Band q22.31
Transcripts
ENST00000359246 ENSP00000352185
ENST00000375376 ENSP00000364525
ENST00000610682 ENSP00000479936
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 4 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003713 transcription coactivator activity
GO:0005506 iron ion binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0032454 histone demethylase activity (H3-K9 specific)
GO:0035064 methylated histone binding
GO:0051213 dioxygenase activity
Biological Process
GO:0001889 liver development
GO:0006351 transcription, DNA-templated
GO:0006482 protein demethylation
GO:0033169 histone H3-K9 demethylation
GO:0055114 oxidation-reduction process
GO:0061188 negative regulation of chromatin silencing at rDNA
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000038025
View Gene Order
ENSBTAG00000012922
Not yet available
Pathways
NETPATH
REACTOME
REACT_228178
HDMs demethylate histones pathway
REACT_172623
Chromatin organization pathway
REACT_172633
Chromatin modifying enzymes pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt O75151
TrEMBL
UniProt Splice Variant
Entrez Gene 5253
UniGene Hs.211441 Hs.707326
RefSeq NM_005392 XM_005252051
HUGO HGNC:8920
OMIM 604351
CCDS CCDS35069
HPRD
IMGT
EMBL AB014562 AF043725 AL353629 AL359181 AL834263 CH471089
GenPept AAD21791 BAA31637 CAD38938 CAI96110 CAI96111 EAW62867
RNA Seq Atlas 5253

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca