InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PHF2

Summary

InnateDB Protein

IDBP-76771.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PHF2

Protein Name

PHD finger protein 2

Synonyms

CENP-35; GRC5; JHDM1E;

Species

Homo sapiens

Ensembl Protein

ENSP00000352185

InnateDB Gene

IDBG-76769 (PHF2)

Protein Structure

UniProt Annotation

Function

Lysine demethylase that demethylates both histones and non-histone proteins. Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B. Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA. {ECO:0000269PubMed:20129925, ECO:0000269PubMed:21167174, ECO:0000269PubMed:21532585}.

Subcellular Localization

Nucleus, nucleolus {ECO:0000269PubMed:20129925}.

Disease Associations

Tissue Specificity

Widely expressed, including in liver (at protein level). {ECO:0000269PubMed:21532585}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0005506	iron ion binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0032454	histone demethylase activity (H3-K9 specific)
GO:0035064	methylated histone binding
GO:0051213	dioxygenase activity

Biological Process

GO:0001889	liver development
GO:0006351	transcription, DNA-templated
GO:0006482	protein demethylation
GO:0033169	histone H3-K9 demethylation
GO:0055114	oxidation-reduction process
GO:0061188	negative regulation of chromatin silencing at rDNA