Homo sapiens Gene: NEUROD1
Summary
InnateDB Gene IDBG-76792.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NEUROD1
Gene Name neuronal differentiation 1
Synonyms BETA2; BHF-1; bHLHa3; MODY6; NEUROD;
Species Homo sapiens
Ensembl Gene ENSG00000162992
Encoded Proteins
neurogenic differentiation 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the NeuroD family of basic helix-loop-helix (bHLH) transcription factors. The protein forms heterodimers with other bHLH proteins and activates transcription of genes that contain a specific DNA sequence known as the E-box. It regulates expression of the insulin gene, and mutations in this gene result in type II diabetes mellitus. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:181673088-181680876
Strand Reverse strand
Band q31.3
Transcripts
ENST00000295108 ENSP00000295108
ENST00000496876
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001102 RNA polymerase II activating transcription factor binding
GO:0001105 RNA polymerase II transcription coactivator activity
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0043565 sequence-specific DNA binding
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
GO:0070888 E-box binding
Biological Process
GO:0003326 pancreatic A cell fate commitment
GO:0003329 pancreatic PP cell fate commitment
GO:0006351 transcription, DNA-templated
GO:0006913 nucleocytoplasmic transport
GO:0007263 nitric oxide mediated signal transduction
GO:0009749 response to glucose
GO:0009952 anterior/posterior pattern specification
GO:0021542 dentate gyrus development
GO:0021549 cerebellum development
GO:0022008 neurogenesis
GO:0023019 signal transduction involved in regulation of gene expression
GO:0030073 insulin secretion
GO:0030902 hindbrain development
GO:0031018 endocrine pancreas development
GO:0035881 amacrine cell differentiation
GO:0035883 enteroendocrine cell differentiation
GO:0042493 response to drug
GO:0042593 glucose homeostasis
GO:0043010 camera-type eye development
GO:0043065 positive regulation of apoptotic process
GO:0045165 cell fate commitment
GO:0045597 positive regulation of cell differentiation
GO:0045664 regulation of neuron differentiation
GO:0045666 positive regulation of neuron differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046426 negative regulation of JAK-STAT cascade
GO:0048562 embryonic organ morphogenesis
GO:0048839 inner ear development
GO:0050796 regulation of insulin secretion
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060730 regulation of intestinal epithelial structure maintenance
GO:0071156 regulation of cell cycle arrest
GO:0071333 cellular response to glucose stimulus
GO:2000675 negative regulation of type B pancreatic cell apoptotic process
GO:2000679 positive regulation of transcription regulatory region DNA binding
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells pathway
Developmental Biology pathway
Regulation of beta-cell development pathway
Regulation of gene expression in beta cells pathway
KEGG
Maturity onset diabetes of the young pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q13562
TrEMBL
UniProt Splice Variant
Entrez Gene 4760
UniGene Hs.614224 Hs.709709 Hs.741598
RefSeq NM_002500
HUGO HGNC:7762
OMIM 601724
CCDS CCDS2283
HPRD 03428
IMGT
EMBL AB009997 AB016079 AB018693 AB593068 AB593069 AB593070 AB593071 AC013733 AF045152 AK313799 BC009046 BT019731 CH471058 D82347 U36472 U50822 U80578
GenPept AAA79702 AAA93480 AAC51318 AAC83145 AAH09046 AAV38536 AAY24267 BAA11558 BAA36519 BAA76603 BAA87605 BAG36535 BAJ84015 BAJ84016 BAJ84017 BAJ84018 EAX10983
RNA Seq Atlas 4760