InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.104022

Summary

InnateDB Gene

IDBG-648841.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.104022

Gene Name

neurogenic differentiation factor 1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000001755

Encoded Proteins

IDBP-701557

neurogenic differentiation factor 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000162992:
This gene encodes a member of the NeuroD family of basic helix-loop-helix (bHLH) transcription factors. The protein forms heterodimers with other bHLH proteins and activates transcription of genes that contain a specific DNA sequence known as the E-box. It regulates expression of the insulin gene, and mutations in this gene result in type II diabetes mellitus. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:14953996-14956356

Strand

Forward strand

Band

Transcripts

ENSBTAT00000002301

ENSBTAP00000002301

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001102	RNA polymerase II activating transcription factor binding
GO:0001105	RNA polymerase II transcription coactivator activity
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0043565	sequence-specific DNA binding
GO:0046982	protein heterodimerization activity
GO:0046983	protein dimerization activity
GO:0070888	E-box binding

Biological Process

GO:0003326	pancreatic A cell fate commitment
GO:0003329	pancreatic PP cell fate commitment
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007263	nitric oxide mediated signal transduction
GO:0007275	multicellular organismal development
GO:0007399	nervous system development
GO:0009749	response to glucose
GO:0009952	anterior/posterior pattern specification
GO:0021542	dentate gyrus development
GO:0021549	cerebellum development
GO:0023019	signal transduction involved in regulation of gene expression
GO:0030073	insulin secretion
GO:0030154	cell differentiation
GO:0030902	hindbrain development
GO:0031018	endocrine pancreas development
GO:0035881	amacrine cell differentiation
GO:0035883	enteroendocrine cell differentiation
GO:0042593	glucose homeostasis
GO:0043010	camera-type eye development
GO:0043065	positive regulation of apoptotic process
GO:0045165	cell fate commitment
GO:0045597	positive regulation of cell differentiation
GO:0045664	regulation of neuron differentiation
GO:0045666	positive regulation of neuron differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046426	negative regulation of JAK-STAT cascade
GO:0048562	embryonic organ morphogenesis
GO:0048839	inner ear development
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060730	regulation of intestinal epithelial structure maintenance
GO:0071156	regulation of cell cycle arrest
GO:2000675	negative regulation of type B pancreatic cell apoptotic process
GO:2000679	positive regulation of transcription regulatory region DNA binding