Version 5.4
Homo sapiens Gene: IER3
Summary
InnateDB Gene IDBG-76842.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IER3
Gene Name immediate early response 3
Synonyms DIF-2; DIF2; GLY96; IEX-1; IEX-1L; IEX1; PRG1
Species Homo sapiens
Ensembl Gene ENSG00000137331
Encoded Proteins
IDBP-76846
immediate early response 3
IDBP-76848
immediate early response 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene functions in the protection of cells from Fas- or tumor necrosis factor type alpha-induced apoptosis. Partially degraded and unspliced transcripts are found after virus infection in vitro, but these transcripts are not found in vivo and do not generate a valid protein. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:30743199-30744554
Strand Reverse strand
Band p21.33
Transcripts
ENST00000376377 ENSP00000365557
ENST00000259874 ENSP00000259874
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 19 [view]
Protein-Protein 19 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0001562 response to protozoan
GO:0003085 negative regulation of systemic arterial blood pressure
GO:0006282 regulation of DNA repair
GO:0006915 apoptotic process
GO:0007095 mitotic G2 DNA damage checkpoint
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0009653 anatomical structure morphogenesis
GO:0043066 negative regulation of apoptotic process
GO:0045732 positive regulation of protein catabolic process
GO:0045820 negative regulation of glycolytic process
GO:0046822 regulation of nucleocytoplasmic transport
GO:0050728 negative regulation of inflammatory response
GO:1901029 negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:2000377 regulation of reactive oxygen species metabolic process
GO:2001020 regulation of response to DNA damage stimulus
Cellular Component
GO:0005634 nucleus
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000003541
View Gene Order
ENSBTAG00000011358
Not yet available
Cross-References
SwissProt P46695
TrEMBL
UniProt Splice Variant
Entrez Gene 8870
UniGene
RefSeq NM_003897
HUGO HGNC:5392
OMIM 602996
CCDS CCDS4689
HPRD 04295
IMGT
EMBL AL662797 BA000025 BC000844 BC005080 BT006703 S81914 X96438 Y14551
GenPept AAB36278 AAH00844 AAH05080 AAP35349 BAB63319 CAA65304 CAA74886 CAI18210
RNA Seq Atlas 8870

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca