InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IER3

Summary

InnateDB Protein

IDBP-76848.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IER3

Protein Name

immediate early response 3

Synonyms

DIF-2; DIF2; GLY96; IEX-1; IEX-1L; IEX1; PRG1;

Species

Homo sapiens

Ensembl Protein

ENSP00000259874

InnateDB Gene

IDBG-76842 (IER3)

Protein Structure

UniProt Annotation

Function

May play a role in the ERK signaling pathway by inhibiting the dephosphorylation of ERK by phosphatase PP2A- PPP2R5C holoenzyme. Acts also as an ERK downstream effector mediating survival. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment. {ECO:0000269PubMed:12356731, ECO:0000269PubMed:16456541, ECO:0000269PubMed:22565310}.

Subcellular Localization

Membrane {ECO:0000269PubMed:12356731}; Single-pass type II membrane protein {ECO:0000269PubMed:12356731}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	19 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0001562	response to protozoan
GO:0003085	negative regulation of systemic arterial blood pressure
GO:0006282	regulation of DNA repair
GO:0006915	apoptotic process
GO:0007095	mitotic G2 DNA damage checkpoint
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0009653	anatomical structure morphogenesis
GO:0043066	negative regulation of apoptotic process
GO:0045732	positive regulation of protein catabolic process
GO:0045820	negative regulation of glycolytic process
GO:0046822	regulation of nucleocytoplasmic transport
GO:0050728	negative regulation of inflammatory response
GO:1901029	negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:2000377	regulation of reactive oxygen species metabolic process
GO:2001020	regulation of response to DNA damage stimulus