Version 5.4
Homo sapiens Gene: TACR2
Summary
InnateDB Gene IDBG-76949.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TACR2
Gene Name tachykinin receptor 2
Synonyms NK2R; NKNAR; SKR; TAC2R
Species Homo sapiens
Ensembl Gene ENSG00000075073
Encoded Proteins
IDBP-76951
tachykinin receptor 2
IDBP-76953
tachykinin receptor 2
IDBP-812914
tachykinin receptor 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neuropeptide substance K, also referred to as neurokinin A. [provided by RefSeq, Jul 2008]
This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5\'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neuropeptide substance K, also referred to as neurokinin A. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:69403903-69416867
Strand Reverse strand
Band q22.1
Transcripts
ENST00000373307 ENSP00000362404
ENST00000373306 ENSP00000362403
ENST00000619173 ENSP00000482436
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0004995 tachykinin receptor activity
GO:0005515 protein binding
GO:0016497 substance K receptor activity
Biological Process
GO:0006936 muscle contraction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007217 tachykinin receptor signaling pathway
GO:0007588 excretion
GO:0014057 positive regulation of acetylcholine secretion
GO:0014827 intestine smooth muscle contraction
GO:0033685 negative regulation of luteinizing hormone secretion
GO:0035106 operant conditioning
GO:0043117 positive regulation of vascular permeability
GO:0043270 positive regulation of ion transport
GO:0051602 response to electrical stimulus
GO:0070459 prolactin secretion
GO:0070474 positive regulation of uterine smooth muscle contraction
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020081
View Gene Order
ENSBTAG00000021664
Not yet available
Pathways
NETPATH
REACTOME
REACT_18283
G alpha (q) signalling events pathway
REACT_120966
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_16963
Tachykinin receptors bind tachykinins pathway
REACT_14819
Peptide ligand-binding receptors pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_21340
GPCR ligand binding pathway
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
hsa04020
Calcium signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt P21452
TrEMBL A6NEW7
UniProt Splice Variant
Entrez Gene 6865
UniGene Hs.88372
RefSeq NM_001057
HUGO HGNC:11527
OMIM 162321
CCDS CCDS7293
HPRD
IMGT
EMBL AB065731 AC016821 AK291996 AY322545 BC096842 CH471083 M57414 M57415 M60281 M60282 M60283 M60284 M75101 M75102 M75103 M75104 M75105
GenPept AAA60347 AAB05897 AAC31760 AAH96842 AAP84358 BAC05952 BAF84685 EAW54324
RNA Seq Atlas 6865

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca