InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TACR2

Summary

InnateDB Protein

IDBP-76953.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TACR2

Protein Name

tachykinin receptor 2

Synonyms

NK2R; NKNAR; SKR; TAC2R;

Species

Homo sapiens

Ensembl Protein

ENSP00000362403

InnateDB Gene

IDBG-76949 (TACR2)

Protein Structure

UniProt Annotation

Function

This is a receptor for the tachykinin neuropeptide substance K (neurokinin A). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance K > neuromedin-K > substance P. {ECO:0000269PubMed:1659297}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004995	tachykinin receptor activity
GO:0005515	protein binding
GO:0016497	substance K receptor activity

Biological Process

GO:0006936	muscle contraction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007217	tachykinin receptor signaling pathway
GO:0007588	excretion
GO:0014057	positive regulation of acetylcholine secretion
GO:0014827	intestine smooth muscle contraction
GO:0033685	negative regulation of luteinizing hormone secretion
GO:0035106	operant conditioning
GO:0043117	positive regulation of vascular permeability
GO:0043270	positive regulation of ion transport
GO:0051602	response to electrical stimulus
GO:0070459	prolactin secretion
GO:0070474	positive regulation of uterine smooth muscle contraction

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000611 Neuropeptide Y receptor family
IPR000913 Neurokinin NK2 receptor
IPR001681 Neurokinin receptor
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx

PFAM

PF00001
PF10320

PRINTS

PR00237
PR01012
PR01025
PR00244

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P21452