InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CALCRL

Summary

InnateDB Gene

IDBG-77141.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CALCRL

Gene Name

calcitonin receptor-like

Synonyms

CGRPR; CRLR

Species

Homo sapiens

Ensembl Gene

ENSG00000064989

Encoded Proteins

IDBP-245792

calcitonin receptor-like

IDBP-293349

calcitonin receptor-like

IDBP-293352

calcitonin receptor-like

IDBP-293343

calcitonin receptor-like

IDBP-387931

calcitonin receptor-like

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:187343129-187448460

Strand

Reverse strand

Band

q32.1

Transcripts

ENST00000392370	ENSP00000376177
ENST00000409998	ENSP00000386972
ENST00000410068	ENSP00000387190
ENST00000410102	ENSP00000386599
ENST00000447403	ENSP00000415626
ENST00000474212
ENST00000485973
ENST00000461244
ENST00000479784

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001605	adrenomedullin receptor activity
GO:0001635	calcitonin gene-related polypeptide receptor activity
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0004948	calcitonin receptor activity
GO:0005515	protein binding
GO:0008565	protein transporter activity

Biological Process

GO:0001525	angiogenesis
GO:0006171	cAMP biosynthetic process
GO:0006816	calcium ion transport
GO:0006937	regulation of muscle contraction
GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007507	heart development
GO:0008284	positive regulation of cell proliferation
GO:0015031	protein transport
GO:0030819	positive regulation of cAMP biosynthetic process
GO:0031623	receptor internalization
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0050728	negative regulation of inflammatory response
GO:0071329	cellular response to sucrose stimulus

Cellular Component

GO:0005764	lysosome
GO:0005768	endosome
GO:0005783	endoplasmic reticulum
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000059588

View Gene Order

ENSBTAG00000008483

Not yet available

Pathways

NETPATH

REACTOME

REACT_19327

G alpha (s) signalling events pathway

REACT_18290

Calcitonin-like ligand receptors pathway

REACT_18372

Class B/2 (Secretin family receptors) pathway

REACT_14797

Signaling by GPCR pathway

REACT_111102

Signal Transduction pathway

REACT_19184

GPCR downstream signaling pathway

REACT_21340

GPCR ligand binding pathway

KEGG

hsa04080

Neuroactive ligand-receptor interaction pathway

hsa04270

Vascular smooth muscle contraction pathway

INOH

PID NCI

Cross-References

SwissProt

Q16602

TrEMBL

D3DPG9

UniProt Splice Variant

Entrez Gene

10203

UniGene

Hs.470882

RefSeq

XM_005246231 XM_005246232 XM_005246234 NM_001271751 NM_005795

HUGO

HGNC:16709

OMIM

114190

CCDS

CCDS2293

HPRD

11809

IMGT

EMBL

AC007319 AC074020 AK291630 AK292998 AY389506 CH471058 L76380 U17473

GenPept

AAA62158 AAC41994 AAQ91332 AAY14806 AAY14996 BAF84319 BAF85687 EAX10925 EAX10926

RNA Seq Atlas

10203