Homo sapiens Gene: CALCRL
Summary
InnateDB Gene IDBG-77141.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CALCRL
Gene Name calcitonin receptor-like
Synonyms CGRPR; CRLR;
Species Homo sapiens
Ensembl Gene ENSG00000064989
Encoded Proteins
calcitonin receptor-like
calcitonin receptor-like
calcitonin receptor-like
calcitonin receptor-like
calcitonin receptor-like
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 2:187343129-187448460
Strand Reverse strand
Band q32.1
Transcripts
ENST00000392370 ENSP00000376177
ENST00000409998 ENSP00000386972
ENST00000410068 ENSP00000387190
ENST00000410102 ENSP00000386599
ENST00000447403 ENSP00000415626
ENST00000474212
ENST00000485973
ENST00000461244
ENST00000479784
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001605 adrenomedullin receptor activity
GO:0001635 calcitonin gene-related polypeptide receptor activity
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G-protein coupled receptor activity
GO:0004948 calcitonin receptor activity
GO:0005515 protein binding
GO:0008565 protein transporter activity
Biological Process
GO:0001525 angiogenesis
GO:0006171 cAMP biosynthetic process
GO:0006816 calcium ion transport
GO:0006937 regulation of muscle contraction
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007507 heart development
GO:0008284 positive regulation of cell proliferation
GO:0015031 protein transport
GO:0030819 positive regulation of cAMP biosynthetic process
GO:0031623 receptor internalization
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0050728 negative regulation of inflammatory response
GO:0071329 cellular response to sucrose stimulus
Cellular Component
GO:0005764 lysosome
GO:0005768 endosome
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
G alpha (s) signalling events pathway
Signaling by GPCR pathway
Signal Transduction pathway
GPCR downstream signaling pathway
Calcitonin-like ligand receptors pathway
GPCR ligand binding pathway
Class B/2 (Secretin family receptors) pathway
KEGG
Neuroactive ligand-receptor interaction pathway
Vascular smooth muscle contraction pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.470882
RefSeq NM_001271751 NM_005795 XM_005246231 XM_005246232 XM_005246234
HUGO
OMIM
CCDS CCDS2293
HPRD 11809
IMGT
EMBL
GenPept
RNA Seq Atlas