Version 5.4
Homo sapiens Gene: GTPBP1
Summary
InnateDB Gene IDBG-7716.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GTPBP1
Gene Name GTP binding protein 1
Synonyms GP-1; GP1; HSPC018
Species Homo sapiens
Ensembl Gene ENSG00000100226
Encoded Proteins
IDBP-7718
GTP binding protein 1
IDBP-376829
GTP binding protein 1
IDBP-376830
GTP binding protein 1
IDBP-586895
GTP binding protein 1
IDBP-583141
GTP binding protein 1
IDBP-584667
GTP binding protein 1
IDBP-588454
GTP binding protein 1
IDBP-586131
GTP binding protein 1
IDBP-596442
GTP binding protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is upregulated by interferon-gamma and encodes a protein that is a member of the AGP11/GTPBP1 family of GTP-binding proteins. A structurally similar protein has been found in mouse, where disruption of the gene for that protein had no observable phenotype. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:38705723-38738299
Strand Forward strand
Band q13.1
Transcripts
ENST00000216044 ENSP00000216044
ENST00000418601 ENSP00000397891
ENST00000458073 ENSP00000388147
ENST00000484657 ENSP00000442881
ENST00000461428
ENST00000488787 ENSP00000439505
ENST00000470836 ENSP00000442628
ENST00000460605
ENST00000475959
ENST00000462332
ENST00000484971 ENSP00000442394
ENST00000487538 ENSP00000445610
ENST00000489527 ENSP00000437430
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated
Total 13 [view]
Protein-Protein 12 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006184 GTP catabolic process
GO:0006955 immune response
GO:0007165 signal transduction
GO:0061014 positive regulation of mRNA catabolic process
Cellular Component
GO:0000177 cytoplasmic exosome (RNase complex)
GO:0005829 cytosol
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000042535
View Gene Order
ENSBTAG00000010324
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.276925 Hs.708670
RefSeq NM_004286 XM_005261857
HUGO
OMIM
CCDS CCDS13977
HPRD 03765
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca