InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GTPBP1

Summary

InnateDB Protein

IDBP-7718.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GTPBP1

Protein Name

GTP binding protein 1

Synonyms

GP-1; GP1; HSPC018;

Species

Homo sapiens

Ensembl Protein

ENSP00000216044

InnateDB Gene

IDBG-7716 (GTPBP1)

Protein Structure

UniProt Annotation

Function

Promotes degradation of target mRNA species. Plays a role in the regulation of circadian mRNA stability. Binds GTP and has GTPase activity (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Experimentally validated
Total	13 [view]
Protein-Protein	12 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005525	GTP binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006184	GTP catabolic process
GO:0006955	immune response
GO:0007165	signal transduction
GO:0061014	positive regulation of mRNA catabolic process

Cellular Component

GO:0000177	cytoplasmic exosome (RNase complex)
GO:0005829	cytosol
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000795 Elongation factor, GTP-binding domain
IPR004160 Translation elongation factor EFTu/EF1A, C-terminal
IPR004161 Translation elongation factor EFTu/EF1A, domain 2
IPR009000 Translation protein, beta-barrel domain
IPR009001 Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00009
PF03143
PF03144

PRINTS

PR00315

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O00178