InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: COL3A1

Summary

InnateDB Gene

IDBG-77195.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

COL3A1

Gene Name

collagen, type III, alpha 1

Synonyms

EDS4A

Species

Homo sapiens

Ensembl Gene

ENSG00000168542

Encoded Proteins

IDBP-77197

collagen, type III, alpha 1

IDBP-77199

collagen, type III, alpha 1

IDBP-387951

collagen, type III, alpha 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes the pro-alpha1 chains of type III collagen, a fibrillar collagen that is found in extensible connective tissues such as skin, lung, uterus, intestine and the vascular system, frequently in association with type I collagen. Mutations in this gene are associated with Ehlers-Danlos syndrome types IV, and with aortic and arterial aneurysms. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish, Feb 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:188974320-189012746

Strand

Forward strand

Band

q32.2

Transcripts

ENST00000304636	ENSP00000304408
ENST00000317840	ENSP00000315243
ENST00000450867	ENSP00000415346
ENST00000470167
ENST00000467886
ENST00000487010

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	13 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005178	integrin binding
GO:0005201	extracellular matrix structural constituent
GO:0005515	protein binding
GO:0046332	SMAD binding
GO:0046872	metal ion binding
GO:0048407	platelet-derived growth factor binding

Biological Process

GO:0001501	skeletal system development
GO:0001568	blood vessel development
GO:0007160	cell-matrix adhesion
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007229	integrin-mediated signaling pathway
GO:0007411	axon guidance
GO:0007507	heart development
GO:0007568	aging
GO:0009314	response to radiation
GO:0009612	response to mechanical stimulus
GO:0018149	peptide cross-linking
GO:0021987	cerebral cortex development
GO:0022617	extracellular matrix disassembly
GO:0030168	platelet activation
GO:0030198	extracellular matrix organization
GO:0030199	collagen fibril organization
GO:0030574	collagen catabolic process
GO:0034097	response to cytokine
GO:0035025	positive regulation of Rho protein signal transduction
GO:0042060	wound healing
GO:0043206	extracellular fibril organization
GO:0043588	skin development
GO:0048565	digestive tract development
GO:0050777	negative regulation of immune response
GO:0071230	cellular response to amino acid stimulus
GO:2001223	negative regulation of neuron migration

Cellular Component

GO:0005576	extracellular region
GO:0005581	collagen trimer
GO:0005586	collagen type III
GO:0005615	extracellular space
GO:0005788	endoplasmic reticulum lumen
GO:0031012	extracellular matrix