Homo sapiens Gene: SLC40A1
Summary
InnateDB Gene IDBG-77320.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC40A1
Gene Name solute carrier family 40 (iron-regulated transporter), member 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000138449
Encoded Proteins
solute carrier family 40 (iron-regulated transporter), member 1
solute carrier family 40 (iron-regulated transporter), member 1
solute carrier family 40 (iron-regulated transporter), member 1
solute carrier family 40 (iron-regulated transporter), member 1
solute carrier family 40 (iron-regulated transporter), member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a cell membrane protein that may be involved in iron export from duodenal epithelial cells. Defects in this gene are a cause of hemochromatosis type 4 (HFE4). [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:189560579-189583758
Strand Reverse strand
Band q32.2
Transcripts
ENST00000261024 ENSP00000261024
ENST00000427241 ENSP00000390005
ENST00000418714
ENST00000455320 ENSP00000413549
ENST00000440626 ENSP00000396134
ENST00000427419 ENSP00000392730
ENST00000479598
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005381 iron ion transmembrane transporter activity
GO:0005515 protein binding
Biological Process
GO:0002260 lymphocyte homeostasis
GO:0003158 endothelium development
GO:0006826 iron ion transport
GO:0006879 cellular iron ion homeostasis
GO:0009653 anatomical structure morphogenesis
GO:0034395 regulation of transcription from RNA polymerase II promoter in response to iron
GO:0034755 iron ion transmembrane transport
GO:0043066 negative regulation of apoptotic process
GO:0048536 spleen development
GO:0055085 transmembrane transport
GO:0060345 spleen trabecula formation
GO:0060586 multicellular organismal iron ion homeostasis
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005771 multivesicular body
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0008021 synaptic vesicle
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Transmembrane transport of small molecules pathway
Iron uptake and transport pathway
Metal ion SLC transporters pathway
SLC-mediated transmembrane transport pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL E7EQF8 Q4PNE6
UniProt Splice Variant
Entrez Gene 30061
UniGene Hs.643005 Hs.718111
RefSeq NM_014585 XM_005246504
HUGO HGNC:10909
OMIM 604653
CCDS CCDS2299
HPRD 05229
IMGT
EMBL AC013439 DQ065759 DQ065760 DQ065761
GenPept AAY78556 AAY78557 AAY78558
RNA Seq Atlas 30061