Version 5.4
Homo sapiens Gene: PIGQ
Summary
InnateDB Gene IDBG-7744.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PIGQ
Gene Name phosphatidylinositol glycan anchor biosynthesis, class Q
Synonyms c407A10.1; GPI1
Species Homo sapiens
Ensembl Gene ENSG00000007541
Encoded Proteins
IDBP-7723
phosphatidylinositol glycan anchor biosynthesis, class Q
IDBP-7746
phosphatidylinositol glycan anchor biosynthesis, class Q
IDBP-7748
phosphatidylinositol glycan anchor biosynthesis, class Q
IDBP-292546
phosphatidylinositol glycan anchor biosynthesis, class Q
IDBP-292548
phosphatidylinositol glycan anchor biosynthesis, class Q
IDBP-361742
phosphatidylinositol glycan anchor biosynthesis, class Q
IDBP-361743
phosphatidylinositol glycan anchor biosynthesis, class Q
IDBP-361751
phosphatidylinositol glycan anchor biosynthesis, class Q
IDBP-361754
phosphatidylinositol glycan anchor biosynthesis, class Q
IDBP-601733
phosphatidylinositol glycan anchor biosynthesis, class Q
IDBP-601185
phosphatidylinositol glycan anchor biosynthesis, class Q
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is involved in the first step in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This gene encodes a N-acetylglucosaminyl transferase component that is part of the complex that catalyzes transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to phosphatidylinositol (PI). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:566995-584136
Strand Forward strand
Band p13.3
Transcripts
ENST00000293874 ENSP00000293874
ENST00000321878 ENSP00000326674
ENST00000026218 ENSP00000026218
ENST00000409527 ENSP00000386760
ENST00000409439 ENSP00000386554
ENST00000422307 ENSP00000413753
ENST00000439574 ENSP00000387820
ENST00000420990 ENSP00000409341
ENST00000443147 ENSP00000410434
ENST00000470411 ENSP00000439650
ENST00000480424
ENST00000476438
ENST00000544860
ENST00000537901
ENST00000540241 ENSP00000439374
ENST00000540548
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006501 C-terminal protein lipidation
GO:0006506 GPI anchor biosynthetic process
GO:0016254 preassembly of GPI anchor in ER membrane
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025728
View Gene Order
ENSBTAG00000016594
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00563
Glycosylphosphatidylinositol(GPI)-anchor biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL B8ZZ29 B8ZZC7 J3QTH6
UniProt Splice Variant
Entrez Gene 9091
UniGene Hs.644153 Hs.734992
RefSeq NM_004204 NM_148920
HUGO HGNC:14135
OMIM 605754
CCDS CCDS10411 CCDS10412
HPRD 09307
IMGT
EMBL Z97986 Z98883
GenPept
RNA Seq Atlas 9091

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca