Version 5.4
Homo sapiens Gene: INPP1
Summary
InnateDB Gene IDBG-77525.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol INPP1
Gene Name inositol polyphosphate-1-phosphatase
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000151689
Encoded Proteins
IDBP-77527
inositol polyphosphate-1-phosphatase
IDBP-245878
inositol polyphosphate-1-phosphatase
IDBP-293304
inositol polyphosphate-1-phosphatase
IDBP-388028
inositol polyphosphate-1-phosphatase
IDBP-388029
inositol polyphosphate-1-phosphatase
IDBP-388030
inositol polyphosphate-1-phosphatase
IDBP-388031
inositol polyphosphate-1-phosphatase
IDBP-388034
inositol polyphosphate-1-phosphatase
IDBP-388035
inositol polyphosphate-1-phosphatase
IDBP-388036
inositol polyphosphate-1-phosphatase
IDBP-388037
inositol polyphosphate-1-phosphatase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes the enzyme inositol polyphosphate-1-phosphatase, one of the enzymes involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 1 of the inositol ring from the polyphosphates inositol 1,4-bisphosphate and inositol 1,3,4-trisphophosphate. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:190343470-190371665
Strand Forward strand
Band q32.2
Transcripts
ENST00000322522 ENSP00000325423
ENST00000392329 ENSP00000376142
ENST00000409027 ENSP00000387079
ENST00000430311 ENSP00000415014
ENST00000413239 ENSP00000391415
ENST00000431594 ENSP00000409786
ENST00000444194 ENSP00000404732
ENST00000417336
ENST00000422454
ENST00000458647 ENSP00000392814
ENST00000423767 ENSP00000395424
ENST00000451089 ENSP00000410662
ENST00000458193 ENSP00000412119
ENST00000487628
ENST00000470892
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004441 inositol-1,4-bisphosphate 1-phosphatase activity
GO:0046872 metal ion binding
GO:0052829 inositol-1,3,4-trisphosphate 1-phosphatase activity
Biological Process
GO:0006796 phosphate-containing compound metabolic process
GO:0007165 signal transduction
GO:0016311 dephosphorylation
GO:0043647 inositol phosphate metabolic process
GO:0044281 small molecule metabolic process
GO:0046854 phosphatidylinositol phosphorylation
Cellular Component
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026102
View Gene Order
ENSBTAG00000007584
Not yet available
Pathways
NETPATH
REACTOME
REACT_150352
Synthesis of IP2, IP, and Ins in the cytosol pathway
REACT_150154
Inositol phosphate metabolism pathway
REACT_111217
Metabolism pathway
KEGG
hsa00562
Inositol phosphate metabolism pathway
hsa04070
Phosphatidylinositol signaling system pathway
INOH
INOH website
Inositol phosphate metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL C9J128 C9J2N5
UniProt Splice Variant
Entrez Gene 3628
UniGene Hs.32309
RefSeq NM_001128928 NM_002194 XM_006712498
HUGO HGNC:6071
OMIM 147263
CCDS CCDS2305
HPRD 00923
IMGT
EMBL AC092178
GenPept
RNA Seq Atlas 3628

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca