Version 5.4
Homo sapiens Gene: ACACA
Summary
InnateDB Gene IDBG-775951.1
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ACACA
Gene Name acetyl-CoA carboxylase alpha
Synonyms ACAC; ACACAD; ACC; ACC1; ACCA
Species Homo sapiens
Ensembl Gene ENSG00000278540
Encoded Proteins
IDBP-811245
acetyl-CoA carboxylase alpha
IDBP-811246
acetyl-CoA carboxylase alpha
IDBP-811251
acetyl-CoA carboxylase alpha
IDBP-811252
acetyl-CoA carboxylase alpha
IDBP-811256
acetyl-CoA carboxylase alpha
IDBP-811260
acetyl-CoA carboxylase alpha
IDBP-811262
acetyl-CoA carboxylase alpha
IDBP-811269
acetyl-CoA carboxylase alpha
IDBP-811270
acetyl-CoA carboxylase alpha
IDBP-811273
acetyl-CoA carboxylase alpha
IDBP-811274
acetyl-CoA carboxylase alpha
IDBP-811277
acetyl-CoA carboxylase alpha
IDBP-811281
acetyl-CoA carboxylase alpha
IDBP-811282
acetyl-CoA carboxylase alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5\' sequence and encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:37084988-37406818
Strand Reverse strand
Band q12
Transcripts
ENST00000616317 ENSP00000483300
ENST00000612895 ENSP00000482269
ENST00000614428 ENSP00000478547
ENST00000619546 ENSP00000483969
ENST00000617649 ENSP00000482368
ENST00000614482 ENSP00000480371
ENST00000618053 ENSP00000482064
ENST00000613776
ENST00000618575
ENST00000619245
ENST00000614450
ENST00000612120
ENST00000613146
ENST00000612926
ENST00000615229 ENSP00000482498
ENST00000621960 ENSP00000483696
ENST00000614789 ENSP00000479621
ENST00000617548 ENSP00000481900
ENST00000616352 ENSP00000477912
ENST00000614438 ENSP00000483852
ENST00000612007 ENSP00000484948
ENST00000614333
ENST00000618351
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 58 experimentally validated interaction(s) in this database.
Experimentally validated
Total 58 [view]
Protein-Protein 57 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0003989 acetyl-CoA carboxylase activity
GO:0004075 biotin carboxylase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008716 D-alanine-D-alanine ligase activity
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0001894 tissue homeostasis
GO:0006084 acetyl-CoA metabolic process
GO:0006112 energy reserve metabolic process
GO:0006629 lipid metabolic process
GO:0006633 fatty acid biosynthetic process
GO:0006766 vitamin metabolic process
GO:0006767 water-soluble vitamin metabolic process
GO:0006768 biotin metabolic process
GO:0006853 carnitine shuttle
GO:0008152 metabolic process
GO:0019432 triglyceride biosynthetic process
GO:0031325 positive regulation of cellular metabolic process
GO:0035338 long-chain fatty-acyl-CoA biosynthetic process
GO:0044255 cellular lipid metabolic process
GO:0044268 multicellular organismal protein metabolic process
GO:0044281 small molecule metabolic process
GO:0051289 protein homotetramerization
GO:0055088 lipid homeostasis
GO:2001295 malonyl-CoA biosynthetic process
Cellular Component
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Orthologs
No orthologs found for this gene
Cross-References
SwissProt
TrEMBL A8MYL5
UniProt Splice Variant
Entrez Gene 31
UniGene
RefSeq NM_198834 NM_198836 NM_198837 NM_198838 NM_198839 XM_005257266 XM_005257267 XM_005257268 XM_006725321 XM_006725322
HUGO HGNC:84
OMIM 200350
CCDS CCDS11317 CCDS11318 CCDS42302 CCDS42303
HPRD
IMGT
EMBL AC003103 AC016482 AC068400
GenPept
RNA Seq Atlas 31

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca