InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ACACA

Summary

InnateDB Protein

IDBP-811245.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACACA

Protein Name

acetyl-CoA carboxylase alpha

Synonyms

ACAC; ACACAD; ACC; ACC1; ACCA;

Species

Homo sapiens

Ensembl Protein

ENSP00000483300

InnateDB Gene

IDBG-775951 (ACACA)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 58 experimentally validated interaction(s) in this database.

Experimentally validated
Total	58 [view]
Protein-Protein	57 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0003989	acetyl-CoA carboxylase activity
GO:0004075	biotin carboxylase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008716	D-alanine-D-alanine ligase activity
GO:0016874	ligase activity
GO:0046872	metal ion binding

Biological Process

GO:0001894	tissue homeostasis
GO:0006084	acetyl-CoA metabolic process
GO:0006112	energy reserve metabolic process
GO:0006629	lipid metabolic process
GO:0006633	fatty acid biosynthetic process
GO:0006766	vitamin metabolic process
GO:0006767	water-soluble vitamin metabolic process
GO:0006768	biotin metabolic process
GO:0006853	carnitine shuttle
GO:0008152	metabolic process
GO:0019432	triglyceride biosynthetic process
GO:0031325	positive regulation of cellular metabolic process
GO:0035338	long-chain fatty-acyl-CoA biosynthetic process
GO:0044255	cellular lipid metabolic process
GO:0044268	multicellular organismal protein metabolic process
GO:0044281	small molecule metabolic process
GO:0051289	protein homotetramerization
GO:0055088	lipid homeostasis
GO:2001295	malonyl-CoA biosynthetic process

Cellular Component

GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000022 Carboxyl transferase
IPR000089 Biotin/lipoyl attachment
IPR003135 ATP-grasp fold, ATP-dependent carboxylate-amine ligase-type
IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain
IPR005481 Carbamoyl-phosphate synthase, large subunit, N-terminal
IPR005482 Biotin carboxylase, C-terminal
IPR011053 Single hybrid motif
IPR011054 Rudiment single hybrid motif
IPR011095 D-alanine--D-alanine ligase, C-terminal
IPR011761 ATP-grasp fold
IPR011762 Acetyl-coenzyme A carboxyltransferase, N-terminal
IPR011763 Acetyl-coenzyme A carboxyltransferase, C-terminal
IPR011764 Biotin carboxylation domain
IPR013537 Acetyl-CoA carboxylase, central domain
IPR016185 Pre-ATP-grasp domain
IPR029045 ClpP/crotonase-like domain

PFAM