InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: UHRF1

Summary

InnateDB Gene

IDBG-776333.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UHRF1

Gene Name

ubiquitin-like with PHD and ring finger domains 1

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000276043

Encoded Proteins

IDBP-811569

ubiquitin-like with PHD and ring finger domains 1

IDBP-811572

ubiquitin-like with PHD and ring finger domains 1

IDBP-811575

ubiquitin-like with PHD and ring finger domains 1

IDBP-811579

ubiquitin-like with PHD and ring finger domains 1

IDBP-811582

ubiquitin-like with PHD and ring finger domains 1

IDBP-811584

ubiquitin-like with PHD and ring finger domains 1

IDBP-811585

ubiquitin-like with PHD and ring finger domains 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:4903080-4962154

Strand

Forward strand

Band

p13.3

Transcripts

ENST00000612630	ENSP00000484739
ENST00000620565	ENSP00000478171
ENST00000613817	ENSP00000480214
ENST00000615884	ENSP00000478601
ENST00000622802	ENSP00000479617
ENST00000616255	ENSP00000478348
ENST00000624301	ENSP00000485604

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 56 experimentally validated interaction(s) in this database.

Experimentally validated
Total	56 [view]
Protein-Protein	55 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000987	core promoter proximal region sequence-specific DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0008327	methyl-CpG binding
GO:0016874	ligase activity
GO:0031493	nucleosomal histone binding
GO:0035064	methylated histone binding
GO:0042393	histone binding
GO:0042802	identical protein binding
GO:0044729	hemi-methylated DNA-binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006281	DNA repair
GO:0006351	transcription, DNA-templated
GO:0007049	cell cycle
GO:0008283	cell proliferation
GO:0010216	maintenance of DNA methylation
GO:0010390	histone monoubiquitination
GO:0016574	histone ubiquitination
GO:0032270	positive regulation of cellular protein metabolic process
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051865	protein autoubiquitination
GO:2000373	positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity

Cellular Component

GO:0000790	nuclear chromatin
GO:0000791	euchromatin
GO:0000792	heterochromatin
GO:0005634	nucleus
GO:0005657	replication fork
GO:0005720	nuclear heterochromatin
GO:0016363	nuclear matrix

Orthologs

No orthologs found for this gene

Pathways

NETPATH

REACTOME

REACT_200857

Epigenetic regulation of gene expression pathway

REACT_267652

DNA methylation pathway

REACT_71

Gene Expression pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

Q96T88

TrEMBL

B4E0F9

UniProt Splice Variant

Entrez Gene

29128

UniGene

RefSeq

NM_001048201 NM_001290050 NM_001290051 NM_001290052 NM_013282

HUGO

HGNC:12556

OMIM

607990

CCDS

CCDS74262 CCDS74263

HPRD

IMGT

EMBL

AB075601 AB177623 AB177624 AC027319 AC053467 AF129507 AF274048 AK025578 AK289389 AK303361 AK314579 AY787925 BC113875 CH471139 EF560733

GenPept

AAF28469 AAF64067 AAI13876 AAK55744 AAV40831 ABQ59043 BAB15177 BAC20576 BAF36719 BAF36720 BAF82078 BAG37156 BAG64421 EAW69187

RNA Seq Atlas

29128