InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: UHRF1

Summary

InnateDB Protein

IDBP-811582.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UHRF1

Protein Name

ubiquitin-like with PHD and ring finger domains 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000479617

InnateDB Gene

IDBG-776333 (UHRF1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 56 experimentally validated interaction(s) in this database.

Experimentally validated
Total	56 [view]
Protein-Protein	55 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000987	core promoter proximal region sequence-specific DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0008327	methyl-CpG binding
GO:0016874	ligase activity
GO:0031493	nucleosomal histone binding
GO:0035064	methylated histone binding
GO:0042393	histone binding
GO:0042802	identical protein binding
GO:0044729	hemi-methylated DNA-binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006281	DNA repair
GO:0006351	transcription, DNA-templated
GO:0007049	cell cycle
GO:0008283	cell proliferation
GO:0010216	maintenance of DNA methylation
GO:0010390	histone monoubiquitination
GO:0016574	histone ubiquitination
GO:0032270	positive regulation of cellular protein metabolic process
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051865	protein autoubiquitination
GO:2000373	positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity

Cellular Component

GO:0000790	nuclear chromatin
GO:0000791	euchromatin
GO:0000792	heterochromatin
GO:0005634	nucleus
GO:0005657	replication fork
GO:0005720	nuclear heterochromatin
GO:0016363	nuclear matrix

Protein Structure and Domains

PDB ID

InterPro

IPR000626 Ubiquitin-like
IPR001841 Zinc finger, RING-type
IPR001965 Zinc finger, PHD-type
IPR003105 SRA-YDG
IPR011011 Zinc finger, FYVE/PHD-type
IPR016197 Chromo domain-like
IPR019787 Zinc finger, PHD-finger
IPR021991 Domain of unknown function DUF3590
IPR029071 Ubiquitin-related domain

PFAM