Version 5.4
Homo sapiens Gene: CCL4
Summary
InnateDB Gene IDBG-776851.1
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CCL4
Gene Name chemokine (C-C motif) ligand 4
Synonyms ACT2; AT744.1; G-26; HC21; LAG-1; LAG1; MIP-1-beta; MIP1B; MIP1B1; SCYA2; SCYA4
Species Homo sapiens
Ensembl Gene ENSG00000275302
Encoded Proteins
IDBP-812241
chemokine (C-C motif) ligand 4
IDBP-812245
chemokine (C-C motif) ligand 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a mitogen-inducible monokine and is one of the major HIV-suppressive factors produced by CD8+ T-cells. The encoded protein is secreted and has chemokinetic and inflammatory functions. [provided by RefSeq, Dec 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:36103590-36105621
Strand Forward strand
Band q12
Transcripts
ENST00000615863 ENSP00000482259
ENST00000621626 ENSP00000480569
ENST00000613947
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated
Total 18 [view]
Protein-Protein 15 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005515 protein binding
GO:0008009 chemokine activity
GO:0031726 CCR1 chemokine receptor binding
GO:0031730 CCR5 chemokine receptor binding
GO:0042802 identical protein binding
Biological Process
GO:0006928 cellular component movement
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007155 cell adhesion
GO:0007163 establishment or maintenance of cell polarity
GO:0007165 signal transduction
GO:0007267 cell-cell signaling
GO:0009615 response to virus
GO:0009636 response to toxic substance
GO:0043922 negative regulation by host of viral transcription
GO:0050850 positive regulation of calcium-mediated signaling
GO:0051928 positive regulation of calcium ion transport
GO:0060326 cell chemotaxis
GO:2000503 positive regulation of natural killer cell chemotaxis
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Orthologs
No orthologs found for this gene
Cross-References
SwissProt P13236
TrEMBL Q7M4M2
UniProt Splice Variant
Entrez Gene 6351
UniGene
RefSeq NM_002984 NM_207007
HUGO HGNC:10630
OMIM 182284 603782
CCDS CCDS11308
HPRD
IMGT
EMBL AC003976 AC069363 AY766446 AY766448 AY766459 BC104226 BC104227 BC107433 CR542119 J04130 M23502 M25316 M57503 M69201 M69202 M69203 X16166 X53682 X53683
GenPept AAA36656 AAA36752 AAA51576 AAA57256 AAB00790 AAI04227 AAI04228 AAI07434 AAX07292 AAX07293 AAX07305 AAX07307 CAA34291 CAA37722 CAA37723 CAG46916
RNA Seq Atlas 388372 6351

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca