Version 5.4
Homo sapiens Gene: TXNIP
Summary
InnateDB Gene IDBG-777180.1
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TXNIP
Gene Name thioredoxin interacting protein
Synonyms EST01027; HHCPA78; THIF; VDUP1
Species Homo sapiens
Ensembl Gene ENSG00000265972
Encoded Proteins
IDBP-812697
thioredoxin interacting protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 1:145992435-145996600
Strand Reverse strand
Band q21.1
Transcripts
ENST00000582401 ENSP00000462521
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
Experimentally validated
Total 24 [view]
Protein-Protein 22 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004857 enzyme inhibitor activity
GO:0005515 protein binding
GO:0031625 ubiquitin protein ligase binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006606 protein import into nucleus
GO:0006979 response to oxidative stress
GO:0007049 cell cycle
GO:0009612 response to mechanical stimulus
GO:0009749 response to glucose
GO:0030216 keratinocyte differentiation
GO:0032355 response to estradiol
GO:0032570 response to progesterone
GO:0035872 nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0042127 regulation of cell proliferation
GO:0042493 response to drug
GO:0042542 response to hydrogen peroxide
GO:0043065 positive regulation of apoptotic process
GO:0043086 negative regulation of catalytic activity
GO:0045087 innate immune response
GO:0048008 platelet-derived growth factor receptor signaling pathway
GO:0051592 response to calcium ion
GO:0051782 negative regulation of cell division
GO:0071228 cellular response to tumor cell
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005758 mitochondrial intermembrane space
GO:0005829 cytosol
Orthologs
No orthologs found for this gene
Cross-References
SwissProt Q9H3M7
TrEMBL A0A024R4B7 B4DVM7
UniProt Splice Variant
Entrez Gene 10628
UniGene
RefSeq NM_006472
HUGO HGNC:16952
OMIM 606599
CCDS CCDS72876
HPRD
IMGT
EMBL AB051901 AF333001 AK301148 AK304670 AL138842 AL160282 AY594328 BC093702 BC093704 CH471244 S73591
GenPept AAB31977 AAH93702 AAH93704 AAK37514 AAT01927 BAB18859 BAG62739 BAG65445 CAI22351 EAW71410 EAW71411
RNA Seq Atlas 10628

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca