InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TXNIP

Summary

InnateDB Protein

IDBP-812697.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TXNIP

Protein Name

thioredoxin interacting protein

Synonyms

EST01027; HHCPA78; THIF; VDUP1;

Species

Homo sapiens

Ensembl Protein

ENSP00000462521

InnateDB Gene

IDBG-777180 (TXNIP)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004857	enzyme inhibitor activity
GO:0005515	protein binding
GO:0031625	ubiquitin protein ligase binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006606	protein import into nucleus
GO:0006979	response to oxidative stress
GO:0007049	cell cycle
GO:0009612	response to mechanical stimulus
GO:0009749	response to glucose
GO:0030216	keratinocyte differentiation
GO:0032355	response to estradiol
GO:0032570	response to progesterone
GO:0035872	nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0042127	regulation of cell proliferation
GO:0042493	response to drug
GO:0042542	response to hydrogen peroxide
GO:0043065	positive regulation of apoptotic process
GO:0043086	negative regulation of catalytic activity
GO:0045087	innate immune response
GO:0048008	platelet-derived growth factor receptor signaling pathway
GO:0051592	response to calcium ion
GO:0051782	negative regulation of cell division
GO:0071228	cellular response to tumor cell