Version 5.4
Homo sapiens Gene: GTF2I
Summary
InnateDB Gene IDBG-777373.1
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GTF2I
Gene Name general transcription factor IIi
Synonyms BAP135; BTKAP1; DIWS; GTFII-I; IB291; SPIN; TFII-I; WBS; WBSCR6
Species Homo sapiens
Ensembl Gene ENSG00000263001
Encoded Proteins
IDBP-813049
general transcription factor IIi
IDBP-813051
general transcription factor IIi
IDBP-813052
general transcription factor IIi
IDBP-813053
general transcription factor IIi
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a phosphoprotein containing six characteristic repeat motifs. The encoded protein binds to the initiator element (Inr) and E-box element in promoters and functions as a regulator of transcription. This locus, along with several other neighboring genes, is deleted in Williams-Beuren syndrome. There are many closely related genes and pseudogenes for this gene on chromosome 7. This gene also has pseudogenes on chromosomes 9, 13, and 21. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:74657667-74760692
Strand Forward strand
Band q11.23
Transcripts
ENST00000613513
ENST00000573035 ENSP00000460070
ENST00000614986 ENSP00000484526
ENST00000621734 ENSP00000482476
ENST00000620879 ENSP00000477837
ENST00000620631
ENST00000615596
ENST00000621640
ENST00000621040
ENST00000614048
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 106 experimentally validated interaction(s) in this database.
Experimentally validated
Total 106 [view]
Protein-Protein 104 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0051019 mitogen-activated protein kinase binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0007165 signal transduction
GO:0014886 transition between slow and fast fiber
GO:0016525 negative regulation of angiogenesis
GO:0051481 negative regulation of cytosolic calcium ion concentration
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0042995 cell projection
GO:0043025 neuronal cell body
Orthologs
No orthologs found for this gene
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001163636 NM_001280800 NM_001518 NM_032999 NM_033000 NM_033001 XM_005250291 XM_005250296 XM_006715940 XM_006715941 XM_006715942 XM_006715943 XM_006715944 XM_006715945 XM_006715946
HUGO
OMIM
CCDS CCDS47614 CCDS5573 CCDS5574 CCDS5575 CCDS64680
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca