Version 5.4
Homo sapiens Gene: ADRA2B
Summary
InnateDB Gene IDBG-777473.1
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADRA2B
Gene Name adrenoceptor alpha 2B
Synonyms ADRA2L1; ADRA2RL1; ADRARL1; alpha-2BAR; ALPHA2BAR
Species Homo sapiens
Ensembl Gene ENSG00000274286
Encoded Proteins
IDBP-813056
adrenoceptor alpha 2B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This intronless gene encodes a seven-pass transmembrane protein. This protein is a member of a subfamily of G protein-coupled receptors that regulate neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. [provided by RefSeq, Apr 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:96112875-96116245
Strand Reverse strand
Band q11.2
Transcripts
ENST00000620793 ENSP00000480573
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0004935 adrenergic receptor activity
GO:0004938 alpha2-adrenergic receptor activity
GO:0005515 protein binding
GO:0051379 epinephrine binding
Biological Process
GO:0000165 MAPK cascade
GO:0000187 activation of MAPK activity
GO:0001525 angiogenesis
GO:0003056 regulation of vascular smooth muscle contraction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007267 cell-cell signaling
GO:0007565 female pregnancy
GO:0007596 blood coagulation
GO:0010700 negative regulation of norepinephrine secretion
GO:0030168 platelet activation
GO:0032148 activation of protein kinase B activity
GO:0032811 negative regulation of epinephrine secretion
GO:0035625 epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway
GO:0045666 positive regulation of neuron differentiation
GO:0045777 positive regulation of blood pressure
GO:0070474 positive regulation of uterine smooth muscle contraction
GO:0071883 activation of MAPK activity by adrenergic receptor signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
Orthologs
No orthologs found for this gene
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_000682
HUGO
OMIM
CCDS CCDS56129
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca