InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ADRA2B

Summary

InnateDB Protein

IDBP-813056.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADRA2B

Protein Name

adrenoceptor alpha 2B

Synonyms

ADRA2L1; ADRA2RL1; ADRARL1; alpha-2BAR; ALPHA2BAR;

Species

Homo sapiens

Ensembl Protein

ENSP00000480573

InnateDB Gene

IDBG-777473 (ADRA2B)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004935	adrenergic receptor activity
GO:0004938	alpha2-adrenergic receptor activity
GO:0005515	protein binding
GO:0051379	epinephrine binding

Biological Process

GO:0000165	MAPK cascade
GO:0000187	activation of MAPK activity
GO:0001525	angiogenesis
GO:0003056	regulation of vascular smooth muscle contraction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007267	cell-cell signaling
GO:0007565	female pregnancy
GO:0007596	blood coagulation
GO:0010700	negative regulation of norepinephrine secretion
GO:0030168	platelet activation
GO:0032148	activation of protein kinase B activity
GO:0032811	negative regulation of epinephrine secretion
GO:0035625	epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway
GO:0045666	positive regulation of neuron differentiation
GO:0045777	positive regulation of blood pressure
GO:0070474	positive regulation of uterine smooth muscle contraction
GO:0071883	activation of MAPK activity by adrenergic receptor signaling pathway

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000207 Alpha 2B adrenoceptor
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR002233 Adrenoceptor family
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
IPR019430 7TM GPCR, serpentine receptor class x (Srx)

PFAM

PF00001
PF10320
PF10328

PRINTS

PR00559
PR00237
PR01103

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P18089