Version 5.4
Homo sapiens Gene: SPOCK2
Summary
InnateDB Gene IDBG-77813.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SPOCK2
Gene Name sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
Synonyms testican-2
Species Homo sapiens
Ensembl Gene ENSG00000107742
Encoded Proteins
IDBP-77815
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
IDBP-77817
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
IDBP-379469
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
IDBP-589516
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein which binds with glycosaminoglycans to form part of the extracellular matrix. The protein contains thyroglobulin type-1, follistatin-like, and calcium-binding domains, and has glycosaminoglycan attachment sites in the acidic C-terminal region. Three alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:72059035-72089032
Strand Reverse strand
Band q22.1
Transcripts
ENST00000317376 ENSP00000321108
ENST00000373109 ENSP00000362201
ENST00000412663 ENSP00000397715
ENST00000463279
ENST00000469121
ENST00000460053
ENST00000495888
ENST00000483699
ENST00000536168 ENSP00000439445
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005539 glycosaminoglycan binding
GO:0050840 extracellular matrix binding
Biological Process
GO:0007165 signal transduction
GO:0007416 synapse assembly
GO:0010811 positive regulation of cell-substrate adhesion
GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan
GO:0030198 extracellular matrix organization
GO:0045595 regulation of cell differentiation
Cellular Component
GO:0005578 proteinaceous extracellular matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000058297
View Gene Order
ENSBTAG00000008827
Not yet available
Cross-References
SwissProt
TrEMBL A0A024QZQ5
UniProt Splice Variant
Entrez Gene 9806
UniGene Hs.523009 Hs.623618
RefSeq NM_001134434 NM_001244950 NM_014767 XM_005270302
HUGO HGNC:13564
OMIM 607988
CCDS CCDS44431 CCDS7313
HPRD 12146
IMGT
EMBL CH471083
GenPept EAW54442 EAW54443
RNA Seq Atlas 9806

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca