Version 5.4
Homo sapiens Gene: LST1
Summary
InnateDB Gene IDBG-77937.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LST1
Gene Name leukocyte specific transcript 1
Synonyms B144; D6S49E; LST-1
Species Homo sapiens
Ensembl Gene ENSG00000204482
Encoded Proteins
IDBP-77941
leukocyte specific transcript 1
IDBP-77947
leukocyte specific transcript 1
IDBP-77949
leukocyte specific transcript 1
IDBP-77953
leukocyte specific transcript 1
IDBP-77955
leukocyte specific transcript 1
IDBP-77957
leukocyte specific transcript 1
IDBP-77959
leukocyte specific transcript 1
IDBP-77961
leukocyte specific transcript 1
IDBP-77963
leukocyte specific transcript 1
IDBP-77965
leukocyte specific transcript 1
IDBP-77967
leukocyte specific transcript 1
IDBP-238173
leukocyte specific transcript 1
IDBP-238177
leukocyte specific transcript 1
IDBP-371635
leukocyte specific transcript 1
IDBP-371644
leukocyte specific transcript 1
IDBP-371656
leukocyte specific transcript 1
IDBP-478062
leukocyte specific transcript 1
IDBP-479166
leukocyte specific transcript 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 22589543
LST1 recruits tyrosine-phosphorylated PTPN6 and PTPN11 to the plasma membrane in myeloid leukocytes.
InnateDB Annotation from Orthologs
Summary
PMID 22589543
[Mus musculus] Lst1 recruits tyrosine-phosphorylated Ptpn6 and Ptpn11 to the plasma membrane in myeloid leukocytes. (Demonstrated in human)
Entrez Gene
Summary The protein encoded by this gene is a membrane protein that can inhibit the proliferation of lymphocytes. Expression of this gene is enhanced by lipopolysaccharide, interferon-gamma, and bacteria. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:31586124-31588909
Strand Forward strand
Band p21.33
Transcripts
ENST00000376110 ENSP00000365278
ENST00000376099 ENSP00000365267
ENST00000376096 ENSP00000365264
ENST00000339530 ENSP00000339201
ENST00000376093 ENSP00000365261
ENST00000376092 ENSP00000365260
ENST00000211921 ENSP00000211921
ENST00000376090 ENSP00000365258
ENST00000376089 ENSP00000365257
ENST00000376086 ENSP00000365254
ENST00000303757 ENSP00000303649
ENST00000396112 ENSP00000379418
ENST00000396101 ENSP00000379408
ENST00000418507 ENSP00000405900
ENST00000438075 ENSP00000391929
ENST00000433492 ENSP00000399869
ENST00000419073
ENST00000464526
ENST00000460834
ENST00000490742 ENSP00000418578
ENST00000464044 ENSP00000417645
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0000902 cell morphogenesis
GO:0006955 immune response
GO:0008360 regulation of cell shape
GO:0009653 anatomical structure morphogenesis
GO:0016358 dendrite development
GO:0045087 innate immune response (InnateDB)
GO:0050672 negative regulation of lymphocyte proliferation
Cellular Component
GO:0000139 Golgi membrane
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000073412
View Gene Order
Cross-References
SwissProt O00453
TrEMBL Q5HYT5
UniProt Splice Variant
Entrez Gene 7940
UniGene Hs.436066
RefSeq NM_205837 NM_001166538 NM_007161 NM_205838 NM_205839 NM_205840 XM_006715206 XM_006715209 XM_006715210 XM_006725044 XM_006725047 XM_006725048 XM_006725522 XM_006725525 XM_006725526 XM_006725741 XM_006725744 XM_006725745 XM_006725848 XM_006725851 XM_006725852 XM_006726038 XM_006726041 XM_006726042 XM_006726126 XM_006726129 XM_006726130
HUGO HGNC:14189
OMIM 109170
CCDS CCDS54985 CCDS43450 CCDS4705 CCDS54984 CCDS54986 CCDS54987
HPRD 00172
IMGT
EMBL AF000424 AF000425 AF000426 AF129756 AL662801 AL662847 AL929587 AY852266 BA000025 BC103855 BC103856 BX248519 BX927320 CH471081 CR753892 CR759886 CR942185 U00921 Y18486 Y18487 Y18488 Y18489 Y18490
GenPept AAB57724 AAB86998 AAB86999 AAB87000 AAD18090 AAI03856 AAI03857 AAX45332 BAB63394 CAB59903 CAB59904 CAB59905 CAB59906 CAB60038 CAI17681 CAI17682 CAI17684 CAI17687 CAI18295 CAI18296 CAI18298 CAI18299 CAI18300 CAI18653 CAI18654 CAI18655 CAI18658 CAI18659 CAI41945 CAI41946 CAI41949 CAI41950 CAI41952 CAM26060 CAM45790 CAO72097 CAQ06939 CAQ06940 CAQ06943 CAQ06944 CAQ06946 CAQ06947 CAQ07231 CAQ07232 CAQ07235 CAQ07236 CAQ07238 CAQ07239 CAQ07715 CAQ07716 CAQ07719 CAQ07720 CAQ07722 CAQ07723 CAQ09997 CAQ09998 CAQ10001 CAQ10002 CAQ10004 CAQ10005 EAX03427 EAX03431
RNA Seq Atlas 7940

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca