InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LST1

Summary

InnateDB Protein

IDBP-77967.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LST1

Protein Name

leukocyte specific transcript 1

Synonyms

B144; D6S49E; LST-1;

Species

Homo sapiens

Ensembl Protein

ENSP00000303649

InnateDB Gene

IDBG-77937 (LST1)

Protein Structure

UniProt Annotation

Function

Possible role in modulating immune responses. Induces morphological changes including production of filopodia and microspikes when overexpressed in a variety of cell types and may be involved in dendritic cell maturation. Isoform 1 and isoform 2 have an inhibitory effect on lymphocyte proliferation. {ECO:0000269PubMed:10706707, ECO:0000269PubMed:11478849}.

Subcellular Localization

Membrane; Single-pass membrane protein. Golgi apparatus membrane; Single-pass membrane protein. Endomembrane system; Single-pass membrane protein. Note=Also detected in a perinuclear region corresponding to the localization of the Golgi apparatus and throughout the cytoplasm.

Disease Associations

Tissue Specificity

Expressed in lung, tonsil, thymus, placenta, kidney, fetal spleen, fetal liver and brain. {ECO:0000269PubMed:7590964, ECO:0000269PubMed:9367684}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0000902	cell morphogenesis
GO:0006955	immune response
GO:0008360	regulation of cell shape
GO:0009653	anatomical structure morphogenesis
GO:0016358	dendrite development
GO:0045087	innate immune response (InnateDB)
GO:0050672	negative regulation of lymphocyte proliferation