InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CAMK2G

Summary

InnateDB Gene

IDBG-78703.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CAMK2G

Gene Name

calcium/calmodulin-dependent protein kinase II gamma

Synonyms

CAMK; CAMK-II; CAMKG

Species

Homo sapiens

Ensembl Gene

ENSG00000148660

Encoded Proteins

IDBP-78705

calcium/calmodulin-dependent protein kinase II gamma

IDBP-78707

calcium/calmodulin-dependent protein kinase II gamma

IDBP-78709

calcium/calmodulin-dependent protein kinase II gamma

IDBP-78711

calcium/calmodulin-dependent protein kinase II gamma

IDBP-78713

calcium/calmodulin-dependent protein kinase II gamma

IDBP-240889

calcium/calmodulin-dependent protein kinase II gamma

IDBP-380302

calcium/calmodulin-dependent protein kinase II gamma

IDBP-380303

calcium/calmodulin-dependent protein kinase II gamma

IDBP-380312

calcium/calmodulin-dependent protein kinase II gamma

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The product of this gene is one of the four subunits of an enzyme which belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a gamma chain. Many alternatively spliced transcripts encoding different isoforms have been described but the full-length nature of all the variants has not been determined.[provided by RefSeq, Mar 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:73812501-73874591

Strand

Reverse strand

Band

q22.2

Transcripts

ENST00000351293	ENSP00000277853
ENST00000322680	ENSP00000319060
ENST00000322635	ENSP00000315599
ENST00000372765	ENSP00000361851
ENST00000305762	ENSP00000307082
ENST00000394762	ENSP00000378243
ENST00000423381	ENSP00000410298
ENST00000433289	ENSP00000393784
ENST00000441192	ENSP00000405561
ENST00000472912
ENST00000474131
ENST00000477205
ENST00000492020
ENST00000477652

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	25 [view]
Protein-Protein	24 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004683	calmodulin-dependent protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004723	calcium-dependent protein serine/threonine phosphatase activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0006468	protein phosphorylation
GO:0006816	calcium ion transport
GO:0007268	synaptic transmission
GO:0007399	nervous system development
GO:0014733	regulation of skeletal muscle adaptation
GO:0016311	dephosphorylation
GO:0019221	cytokine-mediated signaling pathway
GO:0030073	insulin secretion
GO:0030154	cell differentiation
GO:0046777	protein autophosphorylation
GO:0051924	regulation of calcium ion transport
GO:0060333	interferon-gamma-mediated signaling pathway
GO:1901897	regulation of relaxation of cardiac muscle

Cellular Component

GO:0005654	nucleoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005954	calcium- and calmodulin-dependent protein kinase complex
GO:0016020	membrane
GO:0030666	endocytic vesicle membrane
GO:0033017	sarcoplasmic reticulum membrane