InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CAMK2G

Summary

InnateDB Protein

IDBP-78707.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CAMK2G

Protein Name

calcium/calmodulin-dependent protein kinase II gamma

Synonyms

CAMK; CAMK-II; CAMKG;

Species

Homo sapiens

Ensembl Protein

ENSP00000319060

InnateDB Gene

IDBG-78703 (CAMK2G)

Protein Structure

UniProt Annotation

Function

Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplsamic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity. In slow- twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin. In neurons, may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. {ECO:0000269PubMed:16690701}.

Subcellular Localization

Sarcoplasmic reticulum membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed in skeletal muscle. {ECO:0000269PubMed:16690701}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	25 [view]
Protein-Protein	24 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004683	calmodulin-dependent protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004723	calcium-dependent protein serine/threonine phosphatase activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0006468	protein phosphorylation
GO:0006816	calcium ion transport
GO:0007268	synaptic transmission
GO:0007399	nervous system development
GO:0014733	regulation of skeletal muscle adaptation
GO:0016311	dephosphorylation
GO:0019221	cytokine-mediated signaling pathway
GO:0030073	insulin secretion
GO:0030154	cell differentiation
GO:0046777	protein autophosphorylation
GO:0051924	regulation of calcium ion transport
GO:0060333	interferon-gamma-mediated signaling pathway
GO:1901897	regulation of relaxation of cardiac muscle

Cellular Component

GO:0005654	nucleoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005954	calcium- and calmodulin-dependent protein kinase complex
GO:0016020	membrane
GO:0030666	endocytic vesicle membrane
GO:0033017	sarcoplasmic reticulum membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR013543 Calcium/calmodulin-dependent protein kinase II, association-domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF08332

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt