Homo sapiens Gene: APOBEC3B | |||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Summary | |||||||||||||||||||
InnateDB Gene | IDBG-7897.6 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | APOBEC3B | ||||||||||||||||||
Gene Name | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B | ||||||||||||||||||
Synonyms | A3B; APOBEC1L; ARCD3; ARP4; bK150C2.2; DJ742C19.2; PHRBNL | ||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Gene | ENSG00000179750 | ||||||||||||||||||
Encoded Proteins |
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
|
||||||||||||||||||
Protein Structure | |||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
InnateDB Annotation | |||||||||||||||||||
Summary |
Deletion of the APOBEC3B gene strongly impacts susceptibility to Plasmodium falciparum malaria.
|
||||||||||||||||||
Entrez Gene | |||||||||||||||||||
Summary |
This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. A hybrid gene results from the deletion of approximately 29.5 kb of sequence between this gene, APOBEC3B, and the adjacent gene APOBEC3A. The breakpoints of the deletion are within the two genes, so the deletion allele is predicted to have the promoter and coding region of APOBEC3A, but the 3' UTR of APOBEC3B. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012] This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. A hybrid gene results from the deletion of approximately 29.5 kb of sequence between this gene, APOBEC3B, and the adjacent gene APOBEC3A. The breakpoints of the deletion are within the two genes, so the deletion allele is predicted to have the promoter and coding region of APOBEC3A, but the 3\' UTR of APOBEC3B. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012] |
||||||||||||||||||
Gene Information | |||||||||||||||||||
Type | Protein coding | ||||||||||||||||||
Genomic Location | Chromosome 22:38982347-38992804 | ||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||
Band | q13.1 | ||||||||||||||||||
Transcripts |
|
||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
|
||||||||||||||||||
Gene Ontology | |||||||||||||||||||
Molecular Function |
|
||||||||||||||||||
Biological Process |
|
||||||||||||||||||
Cellular Component |
|
||||||||||||||||||
Orthologs | |||||||||||||||||||
No orthologs found for this gene | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | Q9UH17 | ||||||||||||||||||
TrEMBL | |||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 9582 | ||||||||||||||||||
UniGene | Hs.226307 | ||||||||||||||||||
RefSeq | NM_001270411 NM_004900 | ||||||||||||||||||
HUGO | HGNC:17352 | ||||||||||||||||||
OMIM | 607110 | ||||||||||||||||||
CCDS | CCDS58807 CCDS13982 | ||||||||||||||||||
HPRD | 06169 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AL022318 AY743217 BC053859 CT841510 U61083 U61084 | ||||||||||||||||||
GenPept | AAD00089 AAD00090 AAH53859 AAW31743 CAB45270 CAJ86440 CAQ09851 | ||||||||||||||||||
RNA Seq Atlas | 9582 | ||||||||||||||||||