InnateDB Protein
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IDBP-7901.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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APOBEC3B
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Protein Name
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apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
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Synonyms
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A3B; APOBEC1L; ARCD3; ARP4; bK150C2.2; DJ742C19.2; PHRBNL;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000338897
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InnateDB Gene
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IDBG-7897 (APOBEC3B)
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Protein Structure
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Function |
DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination- independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double- stranded RNA. Exhibits antiviral activity against simian immunodeficiency virus (SIV), hepatitis B virus (HBV) and human T- cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. {ECO:0000269PubMed:12859895, ECO:0000269PubMed:15466872, ECO:0000269PubMed:16060832, ECO:0000269PubMed:16527742, ECO:0000269PubMed:20062055, ECO:0000269PubMed:22457529}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:16699599, ECO:0000269PubMed:18667511, ECO:0000269PubMed:21835787, ECO:0000269PubMed:22915799}.
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Disease Associations |
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Tissue Specificity |
Expressed at high and moderate levels in peripheral blood leukocytes, spleen, testes, heart, thymus, prostate and ovary. Also expressed at low levels in several other tissues. {ECO:0000269PubMed:11863358, ECO:0000269PubMed:20308164}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0003824
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catalytic activity
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GO:0008270
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zinc ion binding
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GO:0016814
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hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
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GO:0044822
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poly(A) RNA binding
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GO:0047844
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deoxycytidine deaminase activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR007904
APOBEC-like, C-terminal
IPR013158
APOBEC-like, N-terminal
IPR016193
Cytidine deaminase-like
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PFAM |
PF05240
PF08210
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9UH17
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PhosphoSite |
PhosphoSite-Q9UH17
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
9582
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UniGene |
Hs.226307
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RefSeq |
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HUGO |
HGNC:17352
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OMIM |
607110
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CCDS |
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HPRD |
06169
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IMGT |
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EMBL |
AL022318
AY743217
BC053859
CT841510
U61083
U61084
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GenPept |
AAD00089
AAD00090
AAH53859
AAW31743
CAB45270
CAJ86440
CAQ09851
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